Nascent mutant Huntingtin exon 1 chains do not stall on ribosomes during translation but aggregates do recruit machinery involved in ribosome quality control and RNA.

by Angelique R Ormsby, Dezerae Cox, James Daly, David Priest, Elizabeth Hinde, Danny M Hatters
Published 2020-01-01

Tyrosine 416 is phosphorylated in the closed, repressed conformation of c-Src.

by Sevgi Irtegun, Rebecca J Wood, Angelique R Ormsby, Terrence D Mulhern, Danny M Hatters
Published 2013-01-01

A biosensor-based framework to measure latent proteostasis capacity

by Rebecca J. Wood, Angelique R. Ormsby, Mona Radwan, Dezerae Cox, Abhishek Sharma, Tobias Vöpel, Simon Ebbinghaus, Mikael Oliveberg, Gavin E. Reid, Alex Dickson, Danny M. Hatters
Published 2018-01-01

Huntingtin Inclusions Trigger Cellular Quiescence, Deactivate Apoptosis, and Lead to Delayed Necrosis

by Yasmin M. Ramdzan, Mikhail M. Trubetskov, Angelique R. Ormsby, Estella A. Newcombe, Xiaojing Sui, Mark J. Tobin, Marie N. Bongiovanni, Sally L. Gras, Grant Dewson, Jason M.L. Miller, Steven Finkbeiner, Nagaraj S. Moily, Jonathan Niclis, Clare L. Parish, Anthony W. Purcell, Michael J. Baker, Jacqueline A. Wilce, Saboora Waris, Diana Stojanovski, Till Böcking, Ching-Seng Ang, David B. Ascher, Gavin E. Reid, Danny M. Hatters
Published 2017-05-01