Combining structure and genomics to understand antimicrobial resistance

by Tanushree Tunstall, Stephanie Portelli, Jody Phelan, Taane G. Clark, David B. Ascher, Nicholas Furnham
Published 2020-01-01

TSMDA: Target and symptom-based computational model for miRNA-disease-association prediction

by Korawich Uthayopas, Alex G.C. de Sá, Azadeh Alavi, Douglas E.V. Pires, David B. Ascher
Published 2021-12-01

Distinguishing between PTEN clinical phenotypes through mutation analysis

by Stephanie Portelli, Lucy Barr, Alex G.C. de Sá, Douglas E.V. Pires, David B. Ascher
Published 2021-01-01

Empirical ways to identify novel Bedaquiline resistance mutations in AtpE.

by Malancha Karmakar, Carlos H M Rodrigues, Kathryn E Holt, Sarah J Dunstan, Justin Denholm, David B Ascher
Published 2019-01-01

Structure-guided machine learning prediction of drug resistance mutations in Abelson 1 kinase

by Yunzhuo Zhou, Stephanie Portelli, Megan Pat, Carlos H.M. Rodrigues, Thanh-Binh Nguyen, Douglas E.V. Pires, David B. Ascher
Published 2021-01-01

Unveiling six potent and highly selective antileishmanial agents via the open source compound collection ‘Pathogen Box’ against antimony-sensitive and -resistant Leishmania brazili...

by Juliano A. Souza Silva, Luiza G. Tunes, Roney S. Coimbra, David B. Ascher, Douglas E.V. Pires, Rubens L. Monte-Neto
Published 2021-01-01

Computational saturation mutagenesis to predict structural consequences of systematic mutations in the beta subunit of RNA polymerase in Mycobacterium leprae

by Sundeep Chaitanya Vedithi, Carlos H.M. Rodrigues, Stephanie Portelli, Marcin J. Skwark, Madhusmita Das, David B. Ascher, Tom L. Blundell, Sony Malhotra
Published 2020-01-01

Lst4, the yeast Fnip1/2 orthologue, is a DENN-family protein

by Angela Pacitto, David B. Ascher, Louise H. Wong, Beata K. Blaszczyk, Ravi K. Nookala, Nianshu Zhang, Svetlana Dokudovskaya, Tim P. Levine, Tom L. Blundell
Published 2015-01-01

HARP: a database of structural impacts of systematic missense mutations in drug targets of Mycobacterium leprae

by Sundeep Chaitanya Vedithi, Sony Malhotra, Marcin J. Skwark, Asma Munir, Marta Acebrón-García-De-Eulate, Vaishali P Waman, Ali Alsulami, David B Ascher, Tom L Blundell
Published 2020-01-01

Nedd8 hydrolysis by UCH proteases in Plasmodium parasites.

by Maryia Karpiyevich, Sophie Adjalley, Marco Mol, David B Ascher, Bethany Mason, Gerbrand J van der Heden van Noort, Heike Laman, Huib Ovaa, Marcus C S Lee, Katerina Artavanis-Tsakonas
Published 2019-10-01

Ubiquitin-Dependent Modification of Skeletal Muscle by the Parasitic Nematode, Trichinella spiralis.

by Rhiannon R White, Amy H Ponsford, Michael P Weekes, Rachel B Rodrigues, David B Ascher, Marco Mol, Murray E Selkirk, Steven P Gygi, Christopher M Sanderson, Katerina Artavanis-Tsakonas
Published 2016-11-01

Definition of the immune evasion-replication interface of rabies virus P protein.

by Jingyu Zhan, Angela R Harrison, Stephanie Portelli, Thanh Binh Nguyen, Isshu Kojima, Siqiong Zheng, Fei Yan, Tatsunori Masatani, Stephen M Rawlinson, Ashish Sethi, Naoto Ito, David B Ascher, Gregory W Moseley, Paul R Gooley
Published 2021-07-01

The Presence, Persistence and Functional Properties of Plasmodium vivax Duffy Binding Protein II Antibodies Are Influenced by HLA Class II Allelic Variants.

by Flora S Kano, Flávia A Souza-Silva, Leticia M Torres, Barbara A S Lima, Taís N Sousa, Jéssica R S Alves, Roberto S Rocha, Cor J F Fontes, Bruno A M Sanchez, John H Adams, Cristiana F A Brito, Douglas E V Pires, David B Ascher, Ana Maria Sell, Luzia H Carvalho
Published 2016-12-01

Familial STAG2 germline mutation defines a new human cohesinopathy

by Fernanda C. Soardi, Alice Machado-Silva, Natália D. Linhares, Ge Zheng, Qianhui Qu, Heloísa B. Pena, Thaís M. M. Martins, Helaine G. S. Vieira, Núbia B. Pereira, Raquel C. Melo-Minardi, Carolina C. Gomes, Ricardo S. Gomez, Dawidson A. Gomes, Douglas E. V. Pires, David B. Ascher, Hongtao Yu, Sérgio D. J. Pena
Published 2017-03-01

Huntingtin Inclusions Trigger Cellular Quiescence, Deactivate Apoptosis, and Lead to Delayed Necrosis

by Yasmin M. Ramdzan, Mikhail M. Trubetskov, Angelique R. Ormsby, Estella A. Newcombe, Xiaojing Sui, Mark J. Tobin, Marie N. Bongiovanni, Sally L. Gras, Grant Dewson, Jason M.L. Miller, Steven Finkbeiner, Nagaraj S. Moily, Jonathan Niclis, Clare L. Parish, Anthony W. Purcell, Michael J. Baker, Jacqueline A. Wilce, Saboora Waris, Diana Stojanovski, Till Böcking, Ching-Seng Ang, David B. Ascher, Gavin E. Reid, Danny M. Hatters
Published 2017-05-01

A missense mutation in the MLKL brace region promotes lethal neonatal inflammation and hematopoietic dysfunction

by Joanne M. Hildebrand, Maria Kauppi, Ian J. Majewski, Zikou Liu, Allison J. Cox, Sanae Miyake, Emma J. Petrie, Michael A. Silk, Zhixiu Li, Maria C. Tanzer, Gabriela Brumatti, Samuel N. Young, Cathrine Hall, Sarah E. Garnish, Jason Corbin, Michael D. Stutz, Ladina Di Rago, Pradnya Gangatirkar, Emma C. Josefsson, Kristin Rigbye, Holly Anderton, James A. Rickard, Anne Tripaydonis, Julie Sheridan, Thomas S. Scerri, Victoria E. Jackson, Peter E. Czabotar, Jian-Guo Zhang, Leila Varghese, Cody C. Allison, Marc Pellegrini, Gillian M. Tannahill, Esme C. Hatchell, Tracy A. Willson, Dina Stockwell, Carolyn A. de Graaf, Janelle Collinge, Adrienne Hilton, Natasha Silke, Sukhdeep K. Spall, Diep Chau, Vicki Athanasopoulos, Donald Metcalf, Ronald M. Laxer, Alexander G. Bassuk, Benjamin W. Darbro, Maria A. Fiatarone Singh, Nicole Vlahovich, David Hughes, Maria Kozlovskaia, David B. Ascher, Klaus Warnatz, Nils Venhoff, Jens Thiel, Christine Biben, Stefan Blum, John Reveille, Michael S. Hildebrand, Carola G. Vinuesa, Pamela McCombe, Matthew A. Brown, Benjamin T. Kile, Catriona McLean, Melanie Bahlo, Seth L. Masters, Hiroyasu Nakano, Polly J. Ferguson, James M. Murphy, Warren S. Alexander, John Silke
Published 2020-06-01