Dysregulated G2 phase checkpoint recovery pathway reduces DNA repair efficiency and increases chromosomal instability in a wide range of tumours

by Madushan Fernando, Pascal H. G. Duijf, Martina Proctor, Alexander J. Stevenson, Anna Ehmann, Shivam Vora, Dubravka Skalamera, Mark Adams, Brian Gabrielli
Published 2021-05-01

Combined use of subclinical hydroxyurea and CHK1 inhibitor effectively controls melanoma and lung cancer progression, with reduced normal tissue toxicity compared to gemcitabine

by Zay Yar Oo, Martina Proctor, Alexander J. Stevenson, Deborah Nazareth, Madushan Fernando, Sheena M. Daignault, Catherine Lanagan, Sebastian Walpole, Vanessa Bonazzi, Dubravka Škalamera, Cameron Snell, Nikolas K. Haass, Jill E. Larsen, Brian Gabrielli
Published 2019-07-01

Class IIa Histone Deacetylases Drive Toll-like Receptor-Inducible Glycolysis and Macrophage Inflammatory Responses via Pyruvate Kinase M2

by Kaustav Das Gupta, Melanie R. Shakespear, James E.B. Curson, Ambika M.V. Murthy, Abishek Iyer, Mark P. Hodson, Divya Ramnath, Vikas A. Tillu, Jessica B. von Pein, Robert C. Reid, Kathryn Tunny, Daniel M. Hohenhaus, Shayli Varasteh Moradi, Gregory M. Kelly, Takumi Kobayashi, Jennifer H. Gunter, Alexander J. Stevenson, Weijun Xu, Lin Luo, Alun Jones, Wayne A. Johnston, Antje Blumenthal, Kirill Alexandrov, Brett M. Collins, Jennifer L. Stow, David P. Fairlie, Matthew J. Sweet
Published 2020-02-01