An African Salmonella Typhimurium ST313 sublineage with extensive drug-resistance and signatures of host adaptation

by Sandra Van Puyvelde, Derek Pickard, Koen Vandelannoote, Eva Heinz, Barbara Barbé, Tessa de Block, Simon Clare, Eve L. Coomber, Katherine Harcourt, Sushmita Sridhar, Emily A. Lees, Nicole E. Wheeler, Elizabeth J. Klemm, Laura Kuijpers, Lisette Mbuyi Kalonji, Marie-France Phoba, Dadi Falay, Dauly Ngbonda, Octavie Lunguya, Jan Jacobs, Gordon Dougan, Stijn Deborggraeve
Published 2019-09-01

A proteome-wide genetic investigation identifies several SARS-CoV-2-exploited host targets of clinical relevance

by Mohd Anisul, Jarrod Shilts, Jeremy Schwartzentruber, James Hayhurst, Annalisa Buniello, Elmutaz Shaikho Elhaj Mohammed, Jie Zheng, Michael Holmes, David Ochoa, Miguel Carmona, Joseph Maranville, Tom R Gaunt, Valur Emilsson, Vilmundur Gudnason, Ellen M McDonagh, Gavin J Wright, Maya Ghoussaini, Ian Dunham
Published 2021-08-01

Author Correction: Adaptation of Plasmodium falciparum to humans involved the loss of an ape-specific erythrocyte invasion ligand

by William R. Proto, Sasha V. Siegel, Selasi Dankwa, Weimin Liu, Alison Kemp, Sarah Marsden, Zenon A. Zenonos, Steve Unwin, Paul M. Sharp, Gavin J. Wright, Beatrice H. Hahn, Manoj T. Duraisingh, Julian C. Rayner
Published 2021-02-01

Adaptation of Plasmodium falciparum to humans involved the loss of an ape-specific erythrocyte invasion ligand

by William R. Proto, Sasha V. Siegel, Selasi Dankwa, Weimin Liu, Alison Kemp, Sarah Marsden, Zenon A. Zenonos, Steve Unwin, Paul M. Sharp, Gavin J. Wright, Beatrice H. Hahn, Manoj T. Duraisingh, Julian C. Rayner
Published 2019-10-01

Patterns of database citation in articles and patents indicate long-term scientific and industry value of biological data resources [version 1; referees: 2 approved]

by David Bousfield, Johanna McEntyre, Sameer Velankar, George Papadatos, Alex Bateman, Guy Cochrane, Jee-Hyub Kim, Florian Graef, Vid Vartak, Blaise Alako, Niklas Blomberg
Published 2016-02-01

Distinct genetic architectures and environmental factors associate with host response to the γ2-herpesvirus infections

by Neneh Sallah, Wendell Miley, Nazzarena Labo, Tommy Carstensen, Segun Fatumo, Deepti Gurdasani, Martin O. Pollard, Alexander T. Dilthey, Alexander J. Mentzer, Vickie Marshall, Elena M. Cornejo Castro, Cristina Pomilla, Elizabeth H. Young, Gershim Asiki, Martin L. Hibberd, Manjinder Sandhu, Paul Kellam, Robert Newton, Denise Whitby, Inês Barroso
Published 2020-07-01

The age of heterozygous telomerase mutant parents influences the adult phenotype of their offspring irrespective of genotype in zebrafish [version 2; referees: 2 approved]

by Catherine M. Scahill, Zsofia Digby, Ian M. Sealy, Richard J. White, Neha Wali, John E. Collins, Derek L. Stemple, Elisabeth M. Busch-Nentwich
Published 2018-02-01

The global diversity of Haemonchus contortus is shaped by human intervention and climate

by G. Sallé, S. R. Doyle, J. Cortet, J. Cabaret, M. Berriman, N. Holroyd, J. A. Cotton
Published 2019-10-01

Baseline Gut Microbiota Composition Is Associated With Schistosoma mansoni Infection Burden in Rodent Models

by Alba Cortés, Alba Cortés, Simon Clare, Alice Costain, Alexandre Almeida, Alexandre Almeida, Catherine McCarthy, Katherine Harcourt, Cordelia Brandt, Charlotte Tolley, James Rooney, Matthew Berriman, Trevor Lawley, Andrew S. MacDonald, Gabriel Rinaldi, Cinzia Cantacessi
Published 2020-11-01

Structural rearrangements generate cell-specific, gene-independent CRISPR-Cas9 loss of fitness effects

by Emanuel Gonçalves, Fiona M. Behan, Sandra Louzada, Damien Arnol, Euan A. Stronach, Fengtang Yang, Kosuke Yusa, Oliver Stegle, Francesco Iorio, Mathew J. Garnett
Published 2019-02-01

A global resource for genomic predictions of antimicrobial resistance and surveillance of Salmonella Typhi at pathogenwatch

by Silvia Argimón, Corin A. Yeats, Richard J. Goater, Khalil Abudahab, Benjamin Taylor, Anthony Underwood, Leonor Sánchez-Busó, Vanessa K. Wong, Zoe A. Dyson, Satheesh Nair, Se Eun Park, Florian Marks, Andrew J. Page, Jacqueline A. Keane, Stephen Baker, Kathryn E. Holt, Gordon Dougan, David M. Aanensen
Published 2021-05-01

Contrasting patterns of longitudinal population dynamics and antimicrobial resistance mechanisms in two priority bacterial pathogens over 7 years in a single center

by Matthew J. Ellington, Eva Heinz, Alexander M. Wailan, Matthew J. Dorman, Marcus de Goffau, Amy K. Cain, Sonal P. Henson, Nicholas Gleadall, Christine J. Boinett, Gordon Dougan, Nicholas M. Brown, Neil Woodford, Julian Parkhill, M. Estée Török, Sharon J. Peacock, Nicholas R. Thomson
Published 2019-09-01

Whole-genome sequencing of Schistosoma mansoni reveals extensive diversity with limited selection despite mass drug administration

by Duncan J. Berger, Thomas Crellen, Poppy H. L. Lamberton, Fiona Allan, Alan Tracey, Jennifer D. Noonan, Narcis B. Kabatereine, Edridah M. Tukahebwa, Moses Adriko, Nancy Holroyd, Joanne P. Webster, Matthew Berriman, James A. Cotton
Published 2021-08-01

Myst2/Kat7 histone acetyltransferase interaction proteomics reveals tumour-suppressor Niam as a novel binding partner in embryonic stem cells

by Mercedes Pardo, Lu Yu, Shihpei Shen, Peri Tate, Daniel Bode, Blake L. Letney, Dawn E. Quelle, William Skarnes, Jyoti S. Choudhary
Published 2017-08-01

Expert curation of the human and mouse olfactory receptor gene repertoires identifies conserved coding regions split across two exons

by If H. A. Barnes, Ximena Ibarra-Soria, Stephen Fitzgerald, Jose M. Gonzalez, Claire Davidson, Matthew P. Hardy, Deepa Manthravadi, Laura Van Gerven, Mark Jorissen, Zhen Zeng, Mona Khan, Peter Mombaerts, Jennifer Harrow, Darren W. Logan, Adam Frankish
Published 2020-03-01

Variant calling on the GRCh38 assembly with the data from phase three of the 1000 Genomes Project [version 2; peer review: 2 approved]

by Ernesto Lowy-Gallego, Susan Fairley, Xiangqun Zheng-Bradley, Magali Ruffier, Laura Clarke, Paul Flicek, The 1000 Genomes Project Consortium
Published 2019-12-01

LINE retrotransposons characterize mammalian tissue-specific and evolutionarily dynamic regulatory regions

by Maša Roller, Ericca Stamper, Diego Villar, Osagie Izuogu, Fergal Martin, Aisling M. Redmond, Raghavendra Ramachanderan, Louise Harewood, Duncan T. Odom, Paul Flicek
Published 2021-02-01

A proteomics sample metadata representation for multiomics integration and big data analysis

by Chengxin Dai, Anja Füllgrabe, Julianus Pfeuffer, Elizaveta M. Solovyeva, Jingwen Deng, Pablo Moreno, Selvakumar Kamatchinathan, Deepti Jaiswal Kundu, Nancy George, Silvie Fexova, Björn Grüning, Melanie Christine Föll, Johannes Griss, Marc Vaudel, Enrique Audain, Marie Locard-Paulet, Michael Turewicz, Martin Eisenacher, Julian Uszkoreit, Tim Van Den Bossche, Veit Schwämmle, Henry Webel, Stefan Schulze, David Bouyssié, Savita Jayaram, Vinay Kumar Duggineni, Patroklos Samaras, Mathias Wilhelm, Meena Choi, Mingxun Wang, Oliver Kohlbacher, Alvis Brazma, Irene Papatheodorou, Nuno Bandeira, Eric W. Deutsch, Juan Antonio Vizcaíno, Mingze Bai, Timo Sachsenberg, Lev I. Levitsky, Yasset Perez-Riverol
Published 2021-10-01

Single-cell transcriptomics identifies an effectorness gradient shaping the response of CD4+ T cells to cytokines

by Eddie Cano-Gamez, Blagoje Soskic, Theodoros I. Roumeliotis, Ernest So, Deborah J. Smyth, Marta Baldrighi, David Willé, Nikolina Nakic, Jorge Esparza-Gordillo, Christopher G. C. Larminie, Paola G. Bronson, David F. Tough, Wendy C. Rowan, Jyoti S. Choudhary, Gosia Trynka
Published 2020-04-01

An in vitro erythrocyte preference assay reveals that Plasmodium falciparum parasites prefer Type O over Type A erythrocytes

by Michel Theron, Nadia Cross, Paula Cawkill, Leyla Y. Bustamante, Julian C. Rayner
Published 2018-05-01