Selective Targeting of Epigenetic Readers and Histone Deacetylases in Autoimmune and Inflammatory Diseases: Recent Advances and Future Perspectives

by Mohammed Ghiboub, Ahmed M. I. Elfiky, Menno P. J. de Winther, Nicola R. Harker, David F. Tough, Wouter J. de Jonge
Published 2021-04-01

Toward the discovery of vaccine adjuvants: coupling in silico screening and in vitro analysis of antagonist binding to human and mouse CCR4 receptors.

by Matthew N Davies, Jagadeesh Bayry, Elma Z Tchilian, Janakiraman Vani, Melkote S Shaila, Emily K Forbes, Simon J Draper, Peter C L Beverley, David F Tough, Darren R Flower
Published 2009-11-01

Bromodomain Proteins Contribute to Maintenance of Bloodstream Form Stage Identity in the African Trypanosome.

by Danae Schulz, Monica R Mugnier, Eda-Margaret Paulsen, Hee-Sook Kim, Chun-wa W Chung, David F Tough, Inmaculada Rioja, Rab K Prinjha, F Nina Papavasiliou, Erik W Debler
Published 2015-12-01

BET Bromodomain Inhibitor iBET151 Impedes Human ILC2 Activation and Prevents Experimental Allergic Lung Inflammation

by Bernhard Kerscher, Jillian L. Barlow, Batika M. Rana, Helen E. Jolin, Mayuri Gogoi, Michelle A. Bartholomew, Deepali Jhamb, Ashutosh Pandey, David F. Tough, Antoon J. M. van Oosterhout, Andrew N. J. McKenzie
Published 2019-04-01

Single-cell transcriptomics identifies an effectorness gradient shaping the response of CD4+ T cells to cytokines

by Eddie Cano-Gamez, Blagoje Soskic, Theodoros I. Roumeliotis, Ernest So, Deborah J. Smyth, Marta Baldrighi, David Willé, Nikolina Nakic, Jorge Esparza-Gordillo, Christopher G. C. Larminie, Paola G. Bronson, David F. Tough, Wendy C. Rowan, Jyoti S. Choudhary, Gosia Trynka
Published 2020-04-01

HDAC3 Mediates the Inflammatory Response and LPS Tolerance in Human Monocytes and Macrophages

by Mohammed Ghiboub, Mohammed Ghiboub, Jing Zhao, Andrew Y. F. Li Yim, Andrew Y. F. Li Yim, Ronald Schilderink, Caroline Verseijden, Patricia H. P. van Hamersveld, Jose M. Duarte, Theodorus B. M. Hakvoort, Iris Admiraal, Nicola R. Harker, David F. Tough, Peter Henneman, Menno P. J. de Winther, Menno P. J. de Winther, Wouter J. de Jonge, Wouter J. de Jonge
Published 2020-10-01

Novel Insights Into Rheumatoid Arthritis Through Characterization of Concordant Changes in DNA Methylation and Gene Expression in Synovial Biopsies of Patients With Differing Numbe...

by Andrew Y. F. Li Yim, Andrew Y. F. Li Yim, Enrico Ferrero, Klio Maratou, Huw D. Lewis, George Royal, David F. Tough, Chris Larminie, Marcel M. A. M. Mannens, Peter Henneman, Wouter J. de Jonge, Wouter J. de Jonge, Marleen G. H. van de Sande, Marleen G. H. van de Sande, Danielle M. Gerlag, Rab K. Prinjha, Paul P. Tak, Paul P. Tak, Paul P. Tak, Paul P. Tak
Published 2021-04-01