Lattice engineering enables definition of molecular features allowing for potent small-molecule inhibition of HIV-1 entry

by Yen-Ting Lai, Tao Wang, Sijy O’Dell, Mark K. Louder, Arne Schön, Crystal S. F. Cheung, Gwo-Yu Chuang, Aliaksandr Druz, Bob Lin, Krisha McKee, Dongjun Peng, Yongping Yang, Baoshan Zhang, Alon Herschhorn, Joseph Sodroski, Robert T. Bailer, Nicole A. Doria-Rose, John R. Mascola, David R. Langley, Peter D. Kwong
Published 2019-01-01

Sustained HIV release by single persisting CD4+ T cells during latency disruption

by J.M. Hataye, J.P. Casazza, D.R. Ambrozak, E. Boritz, T. Yamamoto, D.C. Douek, A.S. Perelson, R.A. Koup
Published 2015-12-01

A comprehensive influenza reporter virus panel for high-throughput deep profiling of neutralizing antibodies

by Adrian Creanga, Rebecca A. Gillespie, Brian E. Fisher, Sarah F. Andrews, Julia Lederhofer, Christina Yap, Liam Hatch, Tyler Stephens, Yaroslav Tsybovsky, Michelle C. Crank, Julie E. Ledgerwood, Adrian B. McDermott, John R. Mascola, Barney S. Graham, Masaru Kanekiyo
Published 2021-03-01

Glycan repositioning of influenza hemagglutinin stem facilitates the elicitation of protective cross-group antibody responses

by Seyhan Boyoglu-Barnum, Geoffrey B. Hutchinson, Jeffrey C. Boyington, Syed M. Moin, Rebecca A. Gillespie, Yaroslav Tsybovsky, Tyler Stephens, John R. Vaile, Julia Lederhofer, Kizzmekia S. Corbett, Brian E. Fisher, Hadi M. Yassine, Sarah F. Andrews, Michelle C. Crank, Adrian B. McDermott, John R. Mascola, Barney S. Graham, Masaru Kanekiyo
Published 2020-02-01

An avian influenza H7 DNA priming vaccine is safe and immunogenic in a randomized phase I clinical trial

by Adam D. DeZure, Emily E. Coates, Zonghui Hu, Galina V. Yamshchikov, Kathryn L. Zephir, Mary E. Enama, Sarah H. Plummer, Ingelise J. Gordon, Florence Kaltovich, Sarah Andrews, Adrian McDermott, Michelle C. Crank, Richard A Koup, Richard M. Schwartz, Robert T. Bailer, Xiangjie Sun, John R. Mascola, Terrence M. Tumpey, Barney S. Graham, Julie E. Ledgerwood
Published 2017-06-01

Structural basis of LAIR1 targeting by polymorphic Plasmodium RIFINs

by Kai Xu, Yiran Wang, Chen-Hsiang Shen, Yiwei Chen, Baoshan Zhang, Kevin Liu, Yaroslav Tsybovsky, Shuishu Wang, S. Katie Farney, Jason Gorman, Tyler Stephens, Raffaello Verardi, Yongping Yang, Tongqing Zhou, Gwo-Yu Chuang, Antonio Lanzavecchia, Luca Piccoli, Peter D. Kwong
Published 2021-07-01

Sequence-Signature Optimization Enables Improved Identification of Human HV6-1-Derived Class Antibodies That Neutralize Diverse Influenza A Viruses

by Gwo-Yu Chuang, Chen-Hsiang Shen, Crystal Sao-Fong Cheung, Jason Gorman, Adrian Creanga, M. Gordon Joyce, Kwanyee Leung, Reda Rawi, Lingshu Wang, Eun Sung Yang, Yongping Yang, Baoshan Zhang, Yi Zhang, Masaru Kanekiyo, Tongqing Zhou, Brandon J. DeKosky, Barney S. Graham, John R. Mascola, Peter D. Kwong
Published 2021-05-01

Protection of calves by a prefusion-stabilized bovine RSV F vaccine

by Baoshan Zhang, Lei Chen, Chiara Silacci, Michelle Thom, Jeffrey C. Boyington, Aliaksandr Druz, M. Gordon Joyce, Efrain Guzman, Wing- Pui Kong, Yen-Ting Lai, Guillaume B. E. Stewart-Jones, Yaroslav Tsybovsky, Yongping Yang, Tongqing Zhou, Ulrich Baxa, John R. Mascola, Davide Corti, Antonio Lanzavecchia, Geraldine Taylor, Peter D. Kwong
Published 2017-03-01

Willingness and SARS-CoV-2 Vaccination Coverage among Healthcare Workers in China: A Nationwide Study

by Chao Wang, Yu Wang, Bingfeng Han, Tian-Shuo Zhao, Bei Liu, Hanyu Liu, Linyi Chen, Mingzhu Xie, Hui Zheng, Sihui Zhang, Jing Zeng, Ning-Hua Huang, Juan Du, Yaqiong Liu, Qing-Bin Lu, Fuqiang Cui
Published 2021-09-01

Crystal Structure and Immunogenicity of the DS-Cav1-Stabilized Fusion Glycoprotein From Respiratory Syncytial Virus Subtype B

by M. Gordon Joyce, Amy Bao, Man Chen, Ivelin S. Georgiev, Li Ou, Tatsiana Bylund, Aliaksandr Druz, Wing-Pui Kong, Dongjun Peng, Emily J. Rundlet, Joseph G. Van Galen, Shuishu Wang, Yongping Yang, Baoshan Zhang, Gwo-Yu Chuang, Jason S. McLellan, Barney S. Graham, John R. Mascola, Peter D. Kwong
Published 2019-12-01

Limited clonal relatedness between gut IgA plasma cells and memory B cells after oral immunization

by Mats Bemark, Helena Hazanov, Anneli Strömberg, Rathan Komban, Joel Holmqvist, Sofia Köster, Johan Mattsson, Per Sikora, Ramit Mehr, Nils Y. Lycke
Published 2016-09-01

First Draft Genome Assembly of Redlip Mullet (Liza haematocheila) From Family Mugilidae

by Dileepa S. Liyanage, Minyoung Oh, Welivitiye K.M. Omeka, Qiang Wan, Chang Nam Jin, Ga-Hee Shin, Byeong-Chul Kang, Bo-Hye Nam, Jehee Lee, Jehee Lee
Published 2019-12-01

Comprehensive Flow Cytometry Analysis of PEI-Based Transfections for Virus-Like Particle Production

by Daniel J. Blackstock, Alvenne Goh, Shamitha Shetty, Giulia Fabozzi, Rong Yang, Vera B. Ivleva, Richard Schwartz, Joseph Horwitz
Published 2020-01-01

Functional Profiling of Antibody Immune Repertoires in Convalescent Zika Virus Disease Patients

by Ahmed S. Fahad, Morgan R. Timm, Bharat Madan, Katherine E. Burgomaster, Kimberly A. Dowd, Erica Normandin, Matías F. Gutiérrez-González, Joseph M. Pennington, Matheus Oliveira De Souza, Amy R. Henry, Farida Laboune, Lingshu Wang, David R. Ambrozak, Ingelise J. Gordon, Daniel C. Douek, Julie E. Ledgerwood, Barney S. Graham, Leda R. Castilho, Theodore C. Pierson, John R. Mascola, Brandon J. DeKosky, Brandon J. DeKosky
Published 2021-02-01

Sequencing HIV-neutralizing antibody exons and introns reveals detailed aspects of lineage maturation

by Erik L. Johnson, Nicole A. Doria-Rose, Jason Gorman, Jinal N. Bhiman, Chaim A. Schramm, Ashley Q. Vu, William H. Law, Baoshan Zhang, Valerie Bekker, Salim S. Abdool Karim, Gregory C. Ippolito, Lynn Morris, Penny L. Moore, Peter D. Kwong, John R. Mascola, George Georgiou
Published 2018-10-01

Structure-Based Design of Nipah Virus Vaccines: A Generalizable Approach to Paramyxovirus Immunogen Development

by Rebecca J. Loomis, Guillaume B. E. Stewart-Jones, Yaroslav Tsybovsky, Ria T. Caringal, Kaitlyn M. Morabito, Jason S. McLellan, Amy L. Chamberlain, Sean T. Nugent, Geoffrey B. Hutchinson, Lisa A. Kueltzo, John R. Mascola, Barney S. Graham
Published 2020-06-01

Structural basis of respiratory syncytial virus subtype-dependent neutralization by an antibody targeting the fusion glycoprotein

by Daiyin Tian, Michael B. Battles, Syed M. Moin, Man Chen, Kayvon Modjarrad, Azad Kumar, Masaru Kanekiyo, Kevin W. Graepel, Noor M. Taher, Anne L. Hotard, Martin L. Moore, Min Zhao, Zi-Zheng Zheng, Ning-Shao Xia, Jason S. McLellan, Barney S. Graham
Published 2017-11-01

Rational design of a trispecific antibody targeting the HIV-1 Env with elevated anti-viral activity

by James J. Steinhardt, Javier Guenaga, Hannah L. Turner, Krisha McKee, Mark K. Louder, Sijy O’Dell, Chi-I Chiang, Lin Lei, Andrey Galkin, Alexander K. Andrianov, Nicole A. Doria-Rose, Robert T. Bailer, Andrew B. Ward, John R. Mascola, Yuxing Li
Published 2018-02-01

Disulfide stabilization of human norovirus GI.1 virus-like particles focuses immune response toward blockade epitopes

by Raffaello Verardi, Lisa C. Lindesmith, Yaroslav Tsybovsky, Jason Gorman, Gwo-Yu Chuang, Caitlin E. Edwards, Paul D. Brewer-Jensen, Michael L. Mallory, Li Ou, Arne Schön, Wei Shi, Ena S. Tully, George Georgiou, Ralph S. Baric, Peter D. Kwong
Published 2020-12-01

Both haemagglutinin-specific antibody and T cell responses induced by a chimpanzee adenoviral vaccine confer protection against influenza H7N9 viral challenge

by Xiang Wang, Weihui Fu, Songhua Yuan, Xi Yang, Yufeng Song, Lulu Liu, Yudan Chi, Tao Cheng, Man Xing, Yan Zhang, Chao Zhang, Yong Yang, Caihong Zhu, Xiaoyan Zhang, Sidong Xiong, Jianqing Xu, Dongming Zhou
Published 2017-05-01