Development of broadly neutralizing antibodies in HIV-1 infected elite neutralizers

by Elise Landais, Penny L. Moore
Published 2018-09-01

Combinations of Single Chain Variable Fragments From HIV Broadly Neutralizing Antibodies Demonstrate High Potency and Breadth

by Rebecca T. van Dorsten, Rebecca T. van Dorsten, Kshitij Wagh, Penny L. Moore, Penny L. Moore, Penny L. Moore, Lynn Morris, Lynn Morris, Lynn Morris
Published 2021-09-01

HIV Broadly Neutralizing Antibodies Expressed as IgG3 Preserve Neutralization Potency and Show Improved Fc Effector Function

by Simone I. Richardson, Simone I. Richardson, Frances Ayres, Nelia P. Manamela, Brent Oosthuysen, Zanele Makhado, Bronwen E. Lambson, Bronwen E. Lambson, Lynn Morris, Lynn Morris, Lynn Morris, Penny L. Moore, Penny L. Moore, Penny L. Moore
Published 2021-09-01

Rapid Induction of Multifunctional Antibodies in Rabbits and Macaques by Clade C HIV-1 CAP257 Envelopes Circulating During Epitope-Specific Neutralization Breadth Development

by Delphine C. Malherbe, Constantinos Kurt Wibmer, Molati Nonyane, Jason Reed, D. Noah Sather, David A. Spencer, Jason T. Schuman, Biwei Guo, Shilpi Pandey, Harlan Robins, Byung Park, Deborah H. Fuller, Jonah B. Sacha, Penny L. Moore, Penny L. Moore, Penny L. Moore, Penny L. Moore, Ann J. Hessell, Nancy L. Haigwood, Nancy L. Haigwood
Published 2020-06-01

Antibody-Dependent Cellular Cytotoxicity (ADCC)-Mediating Antibodies Constrain Neutralizing Antibody Escape Pathway

by Dieter Mielke, Gama Bandawe, Justin Pollara, Melissa-Rose Abrahams, Tinashe Nyanhete, Penny L. Moore, Penny L. Moore, Penny L. Moore, Penny L. Moore, Ruwayhida Thebus, Nicole L. Yates, John C. Kappes, John C. Kappes, Christina Ochsenbauer, Nigel Garrett, Nigel Garrett, Salim Abdool Karim, Salim Abdool Karim, Georgia D. Tomaras, David Montefiori, Lynn Morris, Lynn Morris, Lynn Morris, Lynn Morris, Guido Ferrari, Carolyn Williamson, Carolyn Williamson, Carolyn Williamson
Published 2019-12-01

Common helical V1V2 conformations of HIV-1 Envelope expose the α4β7 binding site on intact virions

by Constantinos Kurt Wibmer, Simone I. Richardson, Jason Yolitz, Claudia Cicala, James Arthos, Penny L. Moore, Lynn Morris
Published 2018-10-01

Somatic hypermutation to counter a globally rare viral immunotype drove off-track antibodies in the CAP256-VRC26 HIV-1 V2-directed bNAb lineage.

by David Sacks, Jinal N Bhiman, Kevin Wiehe, Jason Gorman, Peter D Kwong, Lynn Morris, Penny L Moore
Published 2019-09-01

Advancing HIV Vaccine Research With Low-Cost High-Performance Computing Infrastructure: An Alternative Approach for Resource-Limited Settings

by Batsirai M Mabvakure, Raymond Rott, Leslie Dobrowsky, Peter Van Heusden, Lynn Morris, Cathrine Scheepers, Penny L Moore
Published 2019-11-01

Phenotypic deficits in the HIV-1 envelope are associated with the maturation of a V2-directed broadly neutralizing antibody lineage.

by Lucia Reh, Carsten Magnus, Claus Kadelka, Denise Kühnert, Therese Uhr, Jacqueline Weber, Lynn Morris, Penny L Moore, Alexandra Trkola
Published 2018-01-01

Modified Adenovirus Prime-Protein Boost Clade C HIV Vaccine Strategy Results in Reduced Viral DNA in Blood and Tissues Following Tier 2 SHIV Challenge

by Delphine C. Malherbe, Lo Vang, Jason Mendy, Philip T. Barnette, David A. Spencer, Jason Reed, Bettie W. Kareko, D. Noah Sather, D. Noah Sather, Shilpi Pandey, Constantinos K. Wibmer, Constantinos K. Wibmer, Harlan Robins, Deborah H. Fuller, Byung Park, Samir K. Lakhashe, Samir K. Lakhashe, James M. Wilson, Michael K. Axthelm, Ruth M. Ruprecht, Ruth M. Ruprecht, Penny L. Moore, Penny L. Moore, Penny L. Moore, Penny L. Moore, Jonah B. Sacha, Jonah B. Sacha, Jonah B. Sacha, Ann J. Hessell, Jeff Alexander, Nancy L. Haigwood, Nancy L. Haigwood
Published 2021-02-01

Viral escape from HIV-1 neutralizing antibodies drives increased plasma neutralization breadth through sequential recognition of multiple epitopes and immunotypes.

by Constantinos Kurt Wibmer, Jinal N Bhiman, Elin S Gray, Nancy Tumba, Salim S Abdool Karim, Carolyn Williamson, Lynn Morris, Penny L Moore
Published 2013-10-01

The adjuvant AlhydroGel elicits higher antibody titres than AddaVax when combined with HIV-1 subtype C gp140 from CAP256.

by Michiel T van Diepen, Rosamund Chapman, Penny L Moore, Emmanuel Margolin, Tandile Hermanus, Lynn Morris, Phindile Ximba, Edward P Rybicki, Anna-Lise Williamson
Published 2018-01-01

Plasma IL-5 but Not CXCL13 Correlates With Neutralization Breadth in HIV-Infected Children

by Julia Roider, Julia Roider, Julia Roider, Julia Roider, Julia Roider, J. Zachary Porterfield, J. Zachary Porterfield, Paul Ogongo, Paul Ogongo, Paul Ogongo, Maximilian Muenchhoff, Maximilian Muenchhoff, Maximilian Muenchhoff, Maximilian Muenchhoff, Emily Adland, Andreas Groll, Lynn Morris, Lynn Morris, Lynn Morris, Penny L. Moore, Penny L. Moore, Penny L. Moore, Thumbi Ndung'u, Thumbi Ndung'u, Thumbi Ndung'u, Thumbi Ndung'u, Thumbi Ndung'u, Henrik Kløverpris, Henrik Kløverpris, Henrik Kløverpris, Philip J. R. Goulder, Alasdair Leslie, Alasdair Leslie
Published 2019-07-01

HIV-specific Fc effector function early in infection predicts the development of broadly neutralizing antibodies.

by Simone I Richardson, Amy W Chung, Harini Natarajan, Batsirai Mabvakure, Nonhlanhla N Mkhize, Nigel Garrett, Salim Abdool Karim, Penny L Moore, Margaret E Ackerman, Galit Alter, Lynn Morris
Published 2018-04-01

High-Frequency, Functional HIV-Specific T-Follicular Helper and Regulatory Cells Are Present Within Germinal Centers in Children but Not Adults

by Julia Roider, Julia Roider, Julia Roider, Julia Roider, Takashi Maehara, Abigail Ngoepe, Duran Ramsuran, Maximilian Muenchhoff, Maximilian Muenchhoff, Emily Adland, Toby Aicher, Toby Aicher, Toby Aicher, Samuel W. Kazer, Samuel W. Kazer, Samuel W. Kazer, Pieter Jooste, Farina Karim, Warren Kuhn, Alex K. Shalek, Alex K. Shalek, Alex K. Shalek, Thumbi Ndung'u, Thumbi Ndung'u, Thumbi Ndung'u, Thumbi Ndung'u, Thumbi Ndung'u, Lynn Morris, Lynn Morris, Lynn Morris, Penny L. Moore, Penny L. Moore, Penny L. Moore, Shiv Pillai, Henrik Kløverpris, Henrik Kløverpris, Henrik Kløverpris, Philip Goulder, Philip Goulder, Alasdair Leslie, Alasdair Leslie
Published 2018-09-01

IgG3 enhances neutralization potency and Fc effector function of an HIV V2-specific broadly neutralizing antibody.

by Simone I Richardson, Bronwen E Lambson, Andrew R Crowley, Arman Bashirova, Cathrine Scheepers, Nigel Garrett, Salim Abdool Karim, Nonhlanhla N Mkhize, Mary Carrington, Margaret E Ackerman, Penny L Moore, Lynn Morris
Published 2019-12-01

Case report: mechanisms of HIV elite control in two African women

by Yumna Moosa, Ramla F. Tanko, Veron Ramsuran, Ravesh Singh, Mashudu Madzivhandila, Nonhlanhla Yende-Zuma, Melissa-Rose Abrahams, Philippe Selhorst, Kamini Gounder, Penny L. Moore, Carolyn Williamson, Salim S. Abdool Karim, Nigel J. Garrett, Wendy A. Burgers
Published 2018-01-01

Limited neutralizing antibody specificities drive neutralization escape in early HIV-1 subtype C infection.

by Penny L Moore, Nthabeleng Ranchobe, Bronwen E Lambson, Elin S Gray, Eleanor Cave, Melissa-Rose Abrahams, Gama Bandawe, Koleka Mlisana, Salim S Abdool Karim, Carolyn Williamson, Lynn Morris, CAPRISA 002 Study, NIAID Center for HIV/AIDS Vaccine Immunology (CHAVI)
Published 2009-09-01

Longitudinal analysis of subtype C envelope tropism for memory CD4+ T cell subsets over the first 3 years of untreated HIV-1 infection

by Matthew J. Gartner, Paul R. Gorry, Carolin Tumpach, Jingling Zhou, Ashanti Dantanarayana, J. Judy Chang, Thomas A. Angelovich, Paula Ellenberg, Annemarie E. Laumaea, Molati Nonyane, Penny L. Moore, Sharon R. Lewin, Melissa J. Churchill, Jacqueline K. Flynn, Michael Roche
Published 2020-08-01

Effect of HIV Envelope Vaccination on the Subsequent Antibody Response to HIV Infection

by Zanele Ditse, Nonhlanhla N. Mkhize, Michael Yin, Michael Keefer, David C. Montefiori, Georgia D. Tomaras, Gavin Churchyard, Kenneth H. Mayer, Shelly Karuna, Cecilia Morgan, Linda-Gail Bekker, Koleka Mlisana, Glenda Gray, Zoe Moodie, Peter Gilbert, Penny L. Moore, Carolyn Williamson, Lynn Morris
Published 2020-01-01