Distinct disease features in chimpanzees infected with a precore HBV mutant associated with acute liver failure in humans.

by Zhaochun Chen, Ronald E Engle, Chen-Hsiang Shen, Huaying Zhao, Peter W Schuck, Emily J Danoff, Hanh Nguyen, Norihisa Nishimura, Kevin W Bock, Ian N Moore, Peter D Kwong, Robert H Purcell, Sugantha Govindarajan, Patrizia Farci
Published 2020-08-01

Structural basis of LAIR1 targeting by polymorphic Plasmodium RIFINs

by Kai Xu, Yiran Wang, Chen-Hsiang Shen, Yiwei Chen, Baoshan Zhang, Kevin Liu, Yaroslav Tsybovsky, Shuishu Wang, S. Katie Farney, Jason Gorman, Tyler Stephens, Raffaello Verardi, Yongping Yang, Tongqing Zhou, Gwo-Yu Chuang, Antonio Lanzavecchia, Luca Piccoli, Peter D. Kwong
Published 2021-07-01

Improvement of antibody functionality by structure-guided paratope engraftment

by Qingbo Liu, Yen-Ting Lai, Peng Zhang, Mark K. Louder, Amarendra Pegu, Reda Rawi, Mangaiarkarasi Asokan, Xuejun Chen, Chen-Hsiang Shen, Gwo-Yu Chuang, Eun Sung Yang, Huiyi Miao, Yuge Wang, Anthony S. Fauci, Peter D. Kwong, John R. Mascola, Paolo Lusso
Published 2019-02-01

Glycan Positioning Impacts HIV-1 Env Glycan-Shield Density, Function, and Recognition by Antibodies

by Qing Wei, Audra A. Hargett, Barbora Knoppova, Alexandra Duverger, Reda Rawi, Chen-Hsiang Shen, S. Katie Farney, Stacy Hall, Rhubell Brown, Brandon F. Keele, Sonya L. Heath, Michael S. Saag, Olaf Kutsch, Gwo-Yu Chuang, Peter D. Kwong, Zina Moldoveanu, Milan Raska, Matthew B. Renfrow, Jan Novak
Published 2020-11-01

Sequence-Signature Optimization Enables Improved Identification of Human HV6-1-Derived Class Antibodies That Neutralize Diverse Influenza A Viruses

by Gwo-Yu Chuang, Chen-Hsiang Shen, Crystal Sao-Fong Cheung, Jason Gorman, Adrian Creanga, M. Gordon Joyce, Kwanyee Leung, Reda Rawi, Lingshu Wang, Eun Sung Yang, Yongping Yang, Baoshan Zhang, Yi Zhang, Masaru Kanekiyo, Tongqing Zhou, Brandon J. DeKosky, Barney S. Graham, John R. Mascola, Peter D. Kwong
Published 2021-05-01

Structure of Super-Potent Antibody CAP256-VRC26.25 in Complex with HIV-1 Envelope Reveals a Combined Mode of Trimer-Apex Recognition

by Jason Gorman, Gwo-Yu Chuang, Yen-Ting Lai, Chen-Hsiang Shen, Jeffrey C. Boyington, Aliaksandr Druz, Hui Geng, Mark K. Louder, Krisha McKee, Reda Rawi, Raffaello Verardi, Yongping Yang, Baoshan Zhang, Nicole A. Doria-Rose, Bob Lin, Penny L. Moore, Lynn Morris, Lawrence Shapiro, John R. Mascola, Peter D. Kwong
Published 2020-04-01

Paired heavy- and light-chain signatures contribute to potent SARS-CoV-2 neutralization in public antibody responses

by Bailey B. Banach, Gabriele Cerutti, Ahmed S. Fahad, Chen-Hsiang Shen, Matheus Oliveira De Souza, Phinikoula S. Katsamba, Yaroslav Tsybovsky, Pengfei Wang, Manoj S. Nair, Yaoxing Huang, Irene M. Francino-Urdániz, Paul J. Steiner, Matías Gutiérrez-González, Lihong Liu, Sheila N. López Acevedo, Alexandra F. Nazzari, Jacy R. Wolfe, Yang Luo, Adam S. Olia, I-Ting Teng, Jian Yu, Tongqing Zhou, Eswar R. Reddem, Jude Bimela, Xiaoli Pan, Bharat Madan, Amy D. Laflin, Rajani Nimrania, Kwok-Yung Yuen, Timothy A. Whitehead, David D. Ho, Peter D. Kwong, Lawrence Shapiro, Brandon J. DeKosky
Published 2021-10-01

Quantification of the Impact of the HIV-1-Glycan Shield on Antibody Elicitation

by Tongqing Zhou, Nicole A. Doria-Rose, Cheng Cheng, Guillaume B.E. Stewart-Jones, Gwo-Yu Chuang, Michael Chambers, Aliaksandr Druz, Hui Geng, Krisha McKee, Young Do Kwon, Sijy O’Dell, Mallika Sastry, Stephen D. Schmidt, Kai Xu, Lei Chen, Rita E. Chen, Mark K. Louder, Marie Pancera, Timothy G. Wanninger, Baoshan Zhang, Anqi Zheng, S. Katie Farney, Kathryn E. Foulds, Ivelin S. Georgiev, M. Gordon Joyce, Thomas Lemmin, Sandeep Narpala, Reda Rawi, Cinque Soto, John-Paul Todd, Chen-Hsiang Shen, Yaroslav Tsybovsky, Yongping Yang, Peng Zhao, Barton F. Haynes, Leonidas Stamatatos, Michael Tiemeyer, Lance Wells, Diana G. Scorpio, Lawrence Shapiro, Adrian B. McDermott, John R. Mascola, Peter D. Kwong
Published 2017-04-01