LSD1 Inhibition Promotes Epithelial Differentiation through Derepression of Fate-Determining Transcription Factors

by Shaun Egolf, Yann Aubert, Miriam Doepner, Amy Anderson, Alexandra Maldonado-Lopez, Gina Pacella, Jessica Lee, Eun Kyung Ko, Jonathan Zou, Yemin Lan, Cory L. Simpson, Todd Ridky, Brian C. Capell
Published 2019-08-01

Vascular niche IL-6 induces alternative macrophage activation in glioblastoma through HIF-2α

by Qirui Wang, Zhenqiang He, Menggui Huang, Tianrun Liu, Yanling Wang, Haineng Xu, Hao Duan, Peihong Ma, Lin Zhang, Scott S. Zamvil, Juan Hidalgo, Zhenfeng Zhang, Donald M. O’Rourke, Nadia Dahmane, Steven Brem, Yonggao Mou, Yanqing Gong, Yi Fan
Published 2018-02-01

Altered NMDAR signaling underlies autistic-like features in mouse models of CDKL5 deficiency disorder

by Sheng Tang, Barbara Terzic, I-Ting Judy Wang, Nicolas Sarmiento, Katherine Sizov, Yue Cui, Hajime Takano, Eric D. Marsh, Zhaolan Zhou, Douglas A. Coulter
Published 2019-06-01

PDGF-mediated mesenchymal transformation renders endothelial resistance to anti-VEGF treatment in glioblastoma

by Tianrun Liu, Wenjuan Ma, Haineng Xu, Menggui Huang, Duo Zhang, Zhenqiang He, Lin Zhang, Steven Brem, Donald M. O’Rourke, Yanqing Gong, Yonggao Mou, Zhenfeng Zhang, Yi Fan
Published 2018-08-01

Single cell regulatory landscape of the mouse kidney highlights cellular differentiation programs and disease targets

by Zhen Miao, Michael S. Balzer, Ziyuan Ma, Hongbo Liu, Junnan Wu, Rojesh Shrestha, Tamas Aranyi, Amy Kwan, Ayano Kondo, Marco Pontoglio, Junhyong Kim, Mingyao Li, Klaus H. Kaestner, Katalin Susztak
Published 2021-04-01

Long-term outcomes of a phase I study of agonist CD40 antibody and CTLA-4 blockade in patients with metastatic melanoma

by David L. Bajor, Rosemarie Mick, Matthew J. Riese, Alex C. Huang, Brendan Sullivan, Lee P. Richman, Drew A. Torigian, Sangeeth M. George, Erietta Stelekati, Fang Chen, J. Joseph Melenhorst, Simon F. Lacey, Xiaowei Xu, E. John Wherry, Tara C. Gangadhar, Ravi K. Amaravadi, Lynn M. Schuchter, Robert H. Vonderheide
Published 2018-10-01

Behavioral economic implementation strategies to improve serious illness communication between clinicians and high-risk patients with cancer: protocol for a cluster randomized prag...

by Samuel U. Takvorian, Justin Bekelman, Rinad S. Beidas, Robert Schnoll, Alicia B. W. Clifton, Tasnim Salam, Peter Gabriel, E. Paul Wileyto, Callie A. Scott, David A. Asch, Alison M. Buttenheim, Katharine A. Rendle, Krisda Chaiyachati, Rachel C. Shelton, Sue Ware, Corey Chivers, Lynn M. Schuchter, Pallavi Kumar, Lawrence N. Shulman, Nina O’Connor, Adina Lieberman, Kelly Zentgraf, Ravi B. Parikh
Published 2021-09-01

Microtubules orchestrate local translation to enable cardiac growth

by Emily A. Scarborough, Keita Uchida, Maria Vogel, Noa Erlitzki, Meghana Iyer, Sai Aung Phyo, Alexey Bogush, Izhak Kehat, Benjamin L. Prosser
Published 2021-03-01

186 Distinct immune signatures predicting clinical response to PD-1 blockade therapy in gynecological cancers revealed by high-dimensional immune profiling

by Dmitriy Zamarin, Claire Friedman, Yuki Muroyama, Sasikanth Manne, Alexandar Huang, Divij Mathew, Lakshmi Chilukuri, Allison Greenplate, Takuya Ohtani, John Wherry
Published 2020-11-01

Menin‐regulated Pbk controls high fat diet‐induced compensatory beta cell proliferation

by Jian Ma, Bowen Xing, Yan Cao, Xin He, Kate E Bennett, Chao Tong, Chiying An, Taylor Hojnacki, Zijie Feng, Sunbin Deng, Sunbin Ling, Gengchen Xie, Yuan Wu, Yue Ren, Ming Yu, Bryson W Katona, Hongzhe Li, Ali Naji, Xianxin Hua
Published 2021-05-01

Phenotypic and functional analysis of malignant mesothelioma tumor-infiltrating lymphocytes

by Astero Klampatsa, Shaun M. O’Brien, Jeffrey C. Thompson, Abhishek S. Rao, Jason E. Stadanlick, Marina C. Martinez, Maria Liousia, Edward Cantu, Keith Cengel, Edmund K. Moon, Sunil Singhal, Evgeniy B. Eruslanov, Steven M. Albelda
Published 2019-09-01

Evaluation of serious bleeding signals during concomitant use of clopidogrel and hypnotic drugs

by Thanh Phuong Pham Nguyen, Colleen M. Brensinger, Warren B. Bilker, Sean Hennessy, Charles E. Leonard
Published 2021-07-01

The RNA Polymerase III Subunit Polr3b Is Required for the Maintenance of Small Intestinal Crypts in MiceSummary

by Julia E. Kieckhaefer, Sabina Lukovac, Diana Z. Ye, Dolim Lee, Danielle J. Beetler, Michael Pack, Klaus H. Kaestner
Published 2016-11-01

Neuron loss and degeneration in the progression of TDP-43 in frontotemporal lobar degeneration

by Ahmed Yousef, John L. Robinson, David J. Irwin, Matthew D. Byrne, Linda K. Kwong, Edward B. Lee, Yan Xu, Sharon X. Xie, Lior Rennert, EunRan Suh, Vivianna M. Van Deerlin, Murray Grossman, Virginia M.-Y. Lee, John Q. Trojanowski
Published 2017-09-01

Targeting glutamine metabolism slows soft tissue sarcoma growth

by Pearl Lee, Dania Malik, Nicholas Perkons, Peiwei Huangyang, Sanika Khare, Seth Rhoades, Yao-Yu Gong, Michelle Burrows, Jennifer M. Finan, Itzhak Nissim, Terence P. F. Gade, Aalim M. Weljie, M. Celeste Simon
Published 2020-01-01

The Role of Glomerular Epithelial Injury in Kidney Function Decline in Patients With Diabetic Kidney Disease in the TRIDENT Cohort

by Matthew B. Palmer, Amin Abedini, Casey Jackson, Shira Blady, Shatakshee Chatterjee, Katie Marie Sullivan, Raymond R. Townsend, Jens Brodbeck, Salem Almaani, Anand Srivastava, Rupali Avasare, Michael J. Ross, Amy K. Mottl, Christos Argyropoulos, Jonathan Hogan, Katalin Susztak
Published 2021-04-01

Adipocyte ACLY Facilitates Dietary Carbohydrate Handling to Maintain Metabolic Homeostasis in Females

by Sully Fernandez, John M. Viola, AnnMarie Torres, Martina Wallace, Sophie Trefely, Steven Zhao, Hayley C. Affronti, Jivani M. Gengatharan, David A. Guertin, Nathaniel W. Snyder, Christian M. Metallo, Kathryn E. Wellen
Published 2019-05-01

Implementing nudges for suicide prevention in real-world environments: project INSPIRE study protocol

by Molly Davis, Courtney Benjamin Wolk, Shari Jager-Hyman, Rinad S. Beidas, Jami F. Young, Jennifer A. Mautone, Alison M. Buttenheim, David S. Mandell, Kevin G. Volpp, Katherine Wislocki, Anne Futterer, Darby Marx, E. L. Dieckmeyer, Emily M. Becker-Haimes
Published 2020-09-01

Transcriptome signatures associated with meningioma progression

by Angela N. Viaene, Bo Zhang, Maria Martinez-Lage, Chaomei Xiang, Umberto Tosi, Jayesh P. Thawani, Busra Gungor, Yuankun Zhu, Laura Roccograndi, Logan Zhang, Robert L. Bailey, Phillip B. Storm, Donald M. O’Rourke, Adam C. Resnick, M. Sean Grady, Nadia Dahmane
Published 2019-04-01

INSPIIRED: A Pipeline for Quantitative Analysis of Sites of New DNA Integration in Cellular Genomes

by Eric Sherman, Christopher Nobles, Charles C. Berry, Emmanuelle Six, Yinghua Wu, Anatoly Dryga, Nirav Malani, Frances Male, Shantan Reddy, Aubrey Bailey, Kyle Bittinger, John K. Everett, Laure Caccavelli, Mary J. Drake, Paul Bates, Salima Hacein-Bey-Abina, Marina Cavazzana, Frederic D. Bushman
Published 2017-03-01