Structural and energetic profiling of SARS-CoV-2 receptor binding domain antibody recognition and the impact of circulating variants

Structural and energetic profiling of SARS-CoV-2 receptor binding domain antibody recognition and the impact of circulating variants

The SARS-CoV-2 pandemic highlights the need for a detailed molecular understanding of protective antibody responses. This is underscored by the emergence and spread of SARS-CoV-2 variants, including Alpha (B.1.1.7) and Delta (B.1.617.2), some of which appear to be less effectively targeted by curren...

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Bibliographic Details
Main Authors: Gowthaman, R. (Author), Guest, J.D (Author), Mittra, I. (Author), Pierce, B.G (Author), Quackenbush, J. (Author), Taherzadeh, G. (Author), Yin, R. (Author)
Format: Article
Language:English
Published: Public Library of Science 2021
Subjects:
angiotensin converting enzyme 2
Antibodies, Viral
antibody response
Article
binding affinity
binding site
Binding Sites
biology
chemistry
cluster analysis
Cluster Analysis
Computational Biology
computer model
coronavirus spike glycoprotein
COVID-19
cryoelectron microscopy
genetics
human
Humans
hydrogen bond
metabolism
Models, Molecular
molecular docking
molecular model
mutagenesis
phylogenetic tree
protein binding
Protein Binding
protein fingerprinting
receiver operating characteristic
receptor binding
SARS-CoV-2
Severe acute respiratory syndrome coronavirus 2
Spike Glycoprotein, Coronavirus
spike protein, SARS-CoV-2
virology
virus antibody
virus infectivity
virus neutralization
virus strain
X ray diffraction
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