Antibodies, Viral Article Binding Sites COVID-19 Cluster Analysis Computational Biology Humans Models, Molecular Protein Binding SARS-CoV-2 Severe acute respiratory syndrome coronavirus 2 Spike Glycoprotein, Coronavirus X ray diffraction angiotensin converting enzyme 2 antibody response binding affinity binding site biology chemistry cluster analysis computer model coronavirus spike glycoprotein cryoelectron microscopy genetics human hydrogen bond metabolism molecular docking molecular model mutagenesis