Glutamine antagonist JHU083 improves psychosocial behavior and sleep deficits in EcoHIV-infected mice

Glutamine antagonist JHU083 improves psychosocial behavior and sleep deficits in EcoHIV-infected mice

Combined antiretroviral therapy ushered an era of survivable HIV infection in which people living with HIV (PLH) conduct normal life activities and enjoy measurably extended lifespans. However, despite viral control, PLH often experience a variety of cognitive, emotional, and physical phenotypes tha...

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Bibliographic Details
Main Authors: Bell, B.J (Author), Deme, P. (Author), Hasegawa, Y. (Author), Haughey, N. (Author), Hollinger, K.R (Author), Kamiya, A. (Author), Sakamoto, S. (Author), Slusher, B.S (Author), Volsky, D. (Author), Zhu, X. (Author)
Format: Article
Language:English
Published: Elsevier Inc. 2022
Subjects:
6 diazo 5 oxonorleucine
anhedonia
animal behavior
animal experiment
animal model
Article
controlled study
depression
EcoHIV-infected mice
electroencephalography
enzyme activity
enzyme inhibition
excitotoxicity
fragmented sleep
glutamate receptor antagonist
glutamic acid
glutaminase
Glutamine antagonist
Human immunodeficiency virus infection
immune response
jhu 083
male
microglia
Microglial immune genes
mouse
mouse model
nonhuman
open field test
phenotype
Psychosocial deficits
rest
RNA
RNA sequencing
sleep debt
Sleep deficits
sleep disorder
sleep time
sleep waking cycle
social avoidance
social interaction
social psychology
sodium chloride
sucrose preference test
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