6 diazo 5 oxonorleucine Article EcoHIV-infected mice Glutamine antagonist Human immunodeficiency virus infection Microglial immune genes Psychosocial deficits RNA RNA sequencing Sleep deficits anhedonia animal behavior animal experiment animal model controlled study depression electroencephalography enzyme activity enzyme inhibition excitotoxicity fragmented sleep glutamate receptor antagonist glutamic acid glutaminase immune response jhu 083 male microglia mouse mouse model