PUM1 and RNase P genes as potential cell-free DNA markers in breast cancer

Background: Cell-free DNA (cfDNA) is used in clinical research to identify biomarkers for diagnosis of and follow-up on cancer. Here, we propose a fast and innovative approach using traditional housekeeping genes as cfDNA targets in a copy number analysis. We focus on the application of highly sensi...

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Bibliographic Details
Main Authors:	Acosta, O. (Author), Aguilar, A. (Author), Araujo, J. (Author), Buleje, J. (Author), Cotrina, J. (Author), Fujita, R. (Author), Murillo Carrasco, A. (Author), Pinto, J.A (Author), Ponce, J. (Author), Rebaza, P. (Author)
Format:	Article
Language:	English
Published:	John Wiley and Sons Inc 2021
Subjects:	adult advanced cancer Article Biomarkers, Tumor blood breast cancer Breast Neoplasms breast tumor cancer prognosis cancer staging case control study Case-Control Studies cell free DNA cell free nucleic acid cell-free DNA Cell-Free Nucleic Acids controlled study diagnostic accuracy diagnostic test accuracy study digital PCR digital polymerase chain reaction DNA determination DNA marker early cancer early cancer diagnosis epidermal growth factor receptor 2 estrogen estrogen receptor Estrogens female Female fluorescence Fluorescence genetics genomic DNA housekeeping gene human human epidermal growth factor receptor 2 positive breast cancer human tissue Humans liquid biopsy luminal A breast cancer luminal B breast cancer major clinical study metabolism middle aged Middle Aged Neoplasm Staging progesterone receptor PUM1 gene PUM1 protein, human receiver operating characteristic ribonuclease P Ribonuclease P RNA binding protein RNA-Binding Proteins RNase P gene ROC Curve sensitivity and specificity Sensitivity and Specificity spectrophotometry triple negative breast cancer Triple Negative Breast Neoplasms tumor marker ultrasensitive detection method unclassified drug
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PUM1 and RNase P genes as potential cell-free DNA markers in breast cancer

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