Systems modeling of quantitative kinetic data identifies receptor tyrosine kinase-specific resistance mechanisms to MAPK pathway inhibition in cancer

Thesis: Ph. D., Massachusetts Institute of Technology, Department of Biological Engineering, 2017. === Cataloged from PDF version of thesis. === Includes bibliographical references (pages 149-156). === Targeted cancer therapeutics have seen constraint in clinical efficacy due to resistance. Indicato...

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Bibliographic Details
Main Author: Claas, Allison
Other Authors: Douglas A. Lauffenburger.
Format: Others
Language:English
Published: Massachusetts Institute of Technology 2017
Subjects:
Online Access:http://hdl.handle.net/1721.1/112514