Prioritisation and network analysis of Crohn's disease susceptibility genes.

by Daniele Muraro, Douglas A Lauffenburger, Alison Simmons
Published 2014-01-01

A dynamical systems model for combinatorial cancer therapy enhances oncolytic adenovirus efficacy by MEK-inhibition.

by Neda Bagheri, Marisa Shiina, Douglas A Lauffenburger, W Michael Korn
Published 2011-02-01

Acidic extracellular pH promotes activation of integrin α(v)β(3).

by Ranjani K Paradise, Douglas A Lauffenburger, Krystyn J Van Vliet
Published 2011-01-01

Modeling HER2 effects on cell behavior from mass spectrometry phosphotyrosine data.

by Neil Kumar, Alejandro Wolf-Yadlin, Forest M White, Douglas A Lauffenburger
Published 2007-01-01

Computational translation of genomic responses from experimental model systems to humans.

by Douglas K Brubaker, Elizabeth A Proctor, Kevin M Haigis, Douglas A Lauffenburger
Published 2019-01-01

Modeling a snap-action, variable-delay switch controlling extrinsic cell death.

by John G Albeck, John M Burke, Sabrina L Spencer, Douglas A Lauffenburger, Peter K Sorger
Published 2008-12-01

Fuzzy logic analysis of kinase pathway crosstalk in TNF/EGF/insulin-induced signaling.

by Bree B Aldridge, Julio Saez-Rodriguez, Jeremy L Muhlich, Peter K Sorger, Douglas A Lauffenburger
Published 2009-04-01

Training signaling pathway maps to biochemical data with constrained fuzzy logic: quantitative analysis of liver cell responses to inflammatory stimuli.

by Melody K Morris, Julio Saez-Rodriguez, David C Clarke, Peter K Sorger, Douglas A Lauffenburger
Published 2011-03-01

Profiling of metalloprotease activities in cerebrospinal fluids of patients with neoplastic meningitis

by Catharina Conrad, Kristina Dorzweiler, Miles A. Miller, Douglas A. Lauffenburger, Herwig Strik, Jörg W. Bartsch
Published 2017-08-01

MCAM: multiple clustering analysis methodology for deriving hypotheses and insights from high-throughput proteomic datasets.

by Kristen M Naegle, Roy E Welsch, Michael B Yaffe, Forest M White, Douglas A Lauffenburger
Published 2011-07-01

Multiplexed relative and absolute quantitative immunopeptidomics reveals MHC I repertoire alterations induced by CDK4/6 inhibition

by Lauren E. Stopfer, Joshua M. Mesfin, Brian A. Joughin, Douglas A. Lauffenburger, Forest M. White
Published 2020-06-01

Multi-scale in vivo systems analysis reveals the influence of immune cells on TNF-α-induced apoptosis in the intestinal epithelium.

by Ken S Lau, Virna Cortez-Retamozo, Sarah R Philips, Mikael J Pittet, Douglas A Lauffenburger, Kevin M Haigis
Published 2012-01-01

Correction: Multi-Scale In Vivo Systems Analysis Reveals the Influence of Immune Cells on TNF-α-Induced Apoptosis in the Intestinal Epithelium.

by Ken S. Lau, Virna Cortez-Retamozo, Sarah R. Philips, Mikael J. Pittet, Douglas A. Lauffenburger, Kevin M. Haigis
Published 2012-10-01

Non Linear Programming (NLP) formulation for quantitative modeling of protein signal transduction pathways.

by Alexander Mitsos, Ioannis N Melas, Melody K Morris, Julio Saez-Rodriguez, Douglas A Lauffenburger, Leonidas G Alexopoulos
Published 2012-01-01

Analysis of Single-Cell RNA-Seq Identifies Cell-Cell Communication Associated with Tumor Characteristics

by Manu P. Kumar, Jinyan Du, Georgia Lagoudas, Yang Jiao, Andrew Sawyer, Daryl C. Drummond, Douglas A. Lauffenburger, Andreas Raue
Published 2018-11-01

Computational Interspecies Translation Between Alzheimer’s Disease Mouse Models and Human Subjects Identifies Innate Immune Complement, TYROBP, and TAM Receptor Agonist Signatures,...

by Meelim J. Lee, Chuangqi Wang, Molly J. Carroll, Douglas K. Brubaker, Douglas K. Brubaker, Bradley T. Hyman, Douglas A. Lauffenburger
Published 2021-09-01

In vivo microscopy reveals macrophage polarization locally promotes coherent microtubule dynamics in migrating cancer cells

by Gaurav Luthria, Ran Li, Stephanie Wang, Mark Prytyskach, Rainer H. Kohler, Douglas A. Lauffenburger, Timothy J. Mitchison, Ralph Weissleder, Miles A. Miller
Published 2020-07-01

Linking proteomic and transcriptional data through the interactome and epigenome reveals a map of oncogene-induced signaling.

by Shao-shan Carol Huang, David C Clarke, Sara J C Gosline, Adam Labadorf, Candace R Chouinard, William Gordon, Douglas A Lauffenburger, Ernest Fraenkel
Published 2013-01-01

Dissecting N-Glycosylation Dynamics in Chinese Hamster Ovary Cells Fed-batch Cultures using Time Course Omics Analyses

by Madhuresh Sumit, Sepideh Dolatshahi, An-Hsiang Adam Chu, Kaffa Cote, John J. Scarcelli, Jeffrey K. Marshall, Richard J. Cornell, Ron Weiss, Douglas A. Lauffenburger, Bhanu Chandra Mulukutla, Bruno Figueroa, Jr.
Published 2019-02-01

IP-10 (CXCL10) Can Trigger Emergence of Dormant Breast Cancer Cells in a Metastatic Liver Microenvironment

by Amanda M. Clark, Amanda M. Clark, Amanda M. Clark, Haley L. Heusey, Haley L. Heusey, Linda G. Griffith, Douglas. A. Lauffenburger, Alan Wells, Alan Wells, Alan Wells, Alan Wells
Published 2021-05-01