Rapid modelling of cooperating genetic events in cancer through somatic genome editing

Rapid modelling of cooperating genetic events in cancer through somatic genome editing

Cancer is a multistep process that involves mutations and other alterations in oncogenes and tumour suppressor genes. Genome sequencing studies have identified a large collection of genetic alterations that occur in human cancers. However, the determination of which mutations are causally related to...

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Main Authors: Papagiannakopoulos, Thales (Contributor), Romero, Rodrigo (Contributor), Tammela, Tuomas (Contributor), Bauer, Matthew R. (Contributor), Subbaraj, Lakshmipriya (Contributor), Bronson, Roderick T. (Author), Xue, Wen (Contributor), Sanchez-Rivera, Francisco Jav (Contributor), Joshi, Nik (Contributor), Bhutkar, Arjun (Author), Jacks, Tyler E (Author)
Other Authors: Massachusetts Institute of Technology. Department of Biology (Contributor), Massachusetts Institute of Technology. Department of Electrical Engineering and Computer Science (Contributor), Koch Institute for Integrative Cancer Research at MIT (Contributor), Bhutkar, Arjun (AJ) (Contributor), Jacks, Tyler E. (Contributor)
Format: Article
Language:English
Published: Nature Publishing Group, 2015-06-26T15:27:49Z.
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