Metabolic determinants of cancer cell sensitivity to glucose limitation and biguanides

Metabolic determinants of cancer cell sensitivity to glucose limitation and biguanides

As the concentrations of highly consumed nutrients, particularly glucose, are generally lower in tumours than in normal tissues, cancer cells must adapt their metabolism to the tumour microenvironment. A better understanding of these adaptations might reveal cancer cell liabilities that can be explo...

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Main Authors: Possemato, Richard (Contributor), Lorbeer, Franziska K. (Author), Bayraktar, Erol C. (Author), Thiru, Prathapan (Author), Yucel, Burcu (Author), Wang, Tim (Contributor), Chen, Walter W. (Contributor), Clish, Clary (Author), Birsoy, Kivanc (Contributor), Sabatini, David (Author)
Other Authors: Massachusetts Institute of Technology. Department of Biology (Contributor), Whitehead Institute for Biomedical Research (Contributor), Koch Institute for Integrative Cancer Research at MIT (Contributor), Sabatini, David M. (Contributor)
Format: Article
Language:English
Published: Nature Publishing Group, 2015-04-23T18:38:53Z.
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