A lysosome-to-nucleus signalling mechanism senses and regulates the lysosome via mTOR and TFEB

A lysosome-to-nucleus signalling mechanism senses and regulates the lysosome via mTOR and TFEB

The lysosome plays a key role in cellular homeostasis by controlling both cellular clearance and energy production to respond to environmental cues. However, the mechanisms mediating lysosomal adaptation are largely unknown. Here, we show that the Transcription Factor EB (TFEB), a master regulator o...

Full description

Bibliographic Details
Main Authors: Settembre, Carmine (Author), Zoncu, Roberto (Contributor), Medina, Diego L. (Author), Vetrini, Francesco (Author), Erdin, Serkan (Author), Erdin, SerpilUckac (Author), Huynh, Tuong (Author), Ferron, Mathieu (Author), Karsenty, Gerard (Author), Vellard, Michel C. (Author), Facchinetti, Valeria (Author), Ballabio, Andrea (Author), Sabatini, David (Author)
Other Authors: Massachusetts Institute of Technology. Department of Biology (Contributor), Whitehead Institute for Biomedical Research (Contributor), Koch Institute for Integrative Cancer Research at MIT (Contributor), Sabatini, David M. (Contributor)
Format: Article
Language:English
Published: EMBRO Press, 2015-04-23T14:59:31Z.
Subjects:
Article
Online Access:Get fulltext

Internet

Get fulltext

Similar Items