Quantitative-Proteomic Comparison of Alpha and Beta Cells to Uncover Novel Targets for Lineage Reprogramming

Quantitative-Proteomic Comparison of Alpha and Beta Cells to Uncover Novel Targets for Lineage Reprogramming

Type-1 diabetes (T1D) is an autoimmune disease in which insulin-secreting pancreatic beta cells are destroyed by the immune system. An emerging strategy to regenerate beta-cell mass is through transdifferentiation of pancreatic alpha cells to beta cells. We previously reported two small molecules, B...

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Main Authors: Choudhary, Amit (Author), Hu He, Kaihui (Author), Mertins, Philipp (Author), Udeshi, Namrata D. (Author), Dancik, Vlado (Author), Fomina-Yadlin, Dina (Author), Kubicek, Stefan (Author), Clemons, Paul A. (Author), Schreiber, Stuart L. (Author), Wagner, Bridget K. (Author), Carr, Steven A (Author)
Other Authors: Koch Institute for Integrative Cancer Research at MIT (Contributor), Carr, Steven A. (Contributor)
Format: Article
Language:English
Published: Public Library of Science, 2014-06-20T14:33:14Z.
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