A unifying model for mTORC1-mediated regulation of mRNA translation

A unifying model for mTORC1-mediated regulation of mRNA translation

he mTOR complex 1 (mTORC1) kinase nucleates a pathway that promotes cell growth and proliferation and is the target of rapamycin, a drug with many clinical uses. mTORC1 regulates messenger RNA translation, but the overall translational program is poorly defined and no unifying model exists to explai...

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Bibliographic Details
Main Authors: Thoreen, Carson C. (Author), Chantranupong, Lynne (Contributor), Wang, Tim (Author), Gray, Nathanael S. (Author), Keys, Heather Rochelle (Contributor), Sabatini, David (Author)
Other Authors: Massachusetts Institute of Technology. Department of Biology (Contributor), Whitehead Institute for Biomedical Research (Contributor), Sabatini, David M. (Contributor)
Format: Article
Language:English
Published: Nature Publishing Group, 2014-03-14T17:06:14Z.
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