Systematic RNA interference reveals that oncogenic KRAS-driven cancers require TBK1

Systematic RNA interference reveals that oncogenic KRAS-driven cancers require TBK1

The proto-oncogene KRAS is mutated in a wide array of human cancers, most of which are aggressive and respond poorly to standard therapies. Although the identification of specific oncogenes has led to the development of clinically effective, molecularly targeted therapies in some cases, KRAS has rem...

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Main Authors: Sandy, Peter (Contributor), Meylan, Etienne (Contributor), Reiling, Jan H. (Contributor), Hoersch, Sebastian (Contributor), Barbie, David A. (Author), Tamayo, Pablo (Author), Boehm, Jesse S. (Author), Kim, So Young (Author), Moody, Susan E. (Author), Dunn, Ian F. (Author), Schinzel, Anna C. (Author), Scholl, Claudia (Author), Frohling, Stefan (Author), Chan, Edmond M. (Author), Sos, Martin L. (Author), Michel, Kathrin (Author), Mermel, Craig H. (Author), Sabatini, David (Author), Lander, Eric Steven (Author), Jacks, Tyler E (Author)
Other Authors: Massachusetts Institute of Technology. Department of Biology (Contributor), Whitehead Institute for Biomedical Research (Contributor), Koch Institute for Integrative Cancer Research at MIT (Contributor), Sabatini, David M. (Contributor), Lander, Eric S. (Contributor), Jacks, Tyler E. (Contributor)
Format: Article
Language:English
Published: Nature Publishing Group, 2014-01-27T20:47:52Z.
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