The SirT3 Divining Rod Points to Oxidative Stress

Sirtuins are NAD+ dependent deacetylases that counter aging and diseases of aging. Sirtuin research has focused on SirT1, which deacetylates transcription factors and cofactors in the nucleus. More recent findings highlight SirT3 as a mitochondrial sirtuin that regulates metabolism and oxidative str...

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Bibliographic Details
Main Authors: Bell, Eric L. (Contributor), Guarente, Leonard Pershing (Contributor)
Other Authors: Massachusetts Institute of Technology. Department of Biology (Contributor), Paul F. Glenn Center for Biology of Aging Research (Massachusetts Institute of Technology) (Contributor)
Format: Article
Language:English
Published: Elsevier, 2014-01-24T14:00:19Z.
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