Impairment of an Endothelial NAD+-H2S Signaling Network Is a Reversible Cause of Vascular Aging

by Das, Abhirup, Huang, George X., Bonkowski, Michael S., Longchamp, Alban, Li, Catherine, Schultz, Michael B., Kim, Lynn-Jee, Osborne, Brenna, Joshi, Sanket, Lu, Yuancheng, Treviño-Villarreal, Jose Humberto, Kang, Myung-Jin, Hung, Tzong-tyng, Lee, Brendan, Williams, Eric O, Igarashi, Masaki, Mitchell, James R., Wu, Lindsay E., Turner, Nigel, Arany, Zolt, Guarente, Leonard Pershing, Sinclair, David A.
Published 2020

Small-Molecule Allosteric Activators of Sirtuins

by Sinclair, David A., Guarente, Leonard Pershing
Published 2015

Forever Young

by Guarente, Leonard Pershing
Published 2014

Hepatic SIRT1 Attenuates Hepatic Steatosis and Controls Energy Balance in Mice by Inducing Fibroblast Growth Factor 21

by Li, Yu, Wong, Kimberly, Giles, Amber, Jiang, Jianwei, Lee, Jong Woo, Adams, Andrew C., Kharitonenkov, Alexei, Yang, Qin, Gao, Bin, Zang, Mengwei, Guarente, Leonard Pershing
Published 2017

Calorie restriction and sirtuins revisited

by Guarente, Leonard Pershing
Published 2014

Identification of CDCP1 as a hypoxia-inducible factor 2  (HIF-2 ) target gene that is associated with survival in clear cell renal cell carcinoma patients

by Emerling, B. M., Benes, Cyril H., Poulogiannis, G., Courtney, K., Liu, H., Choo-Wing, R., Bellinger, Gary, Tsukazawa, K. S., Brown, V., Signoretti, S., Soltoff, S. P., Cantley, Lewis C., Bell, Eric L.
Published 2013

The Logic Linking Protein Acetylation and Metabolism

by Guarente, Leonard Pershing
Published 2014

High-Fat Diet Triggers Inflammation-Induced Cleavage of SIRT1 in Adipose Tissue To Promote Metabolic Dysfunction

by Chalkiadaki, Angeliki, Guarente, Leonard Pershing
Published 2014

SIRT5 Deacetylates Carbamoyl Phosphate Synthetase 1 and Regulates the Urea Cycle

by Nakagawa, Takashi, Lomb, David J., Haigis, Marcia C., Guarente, Leonard Pershing
Published 2014

The [NAD[superscript +] over Sirtuin] Pathway Modulates Longevity through Activation of Mitochondrial UPR and FOXO Signaling

by Mouchiroud, Laurent, Houtkooper, Riekelt H, Moullan, Norman, Katsyuba, Elena, Ryu, Dongryeol, Canto, Carles, Mottis, Adrienne, Jo, Young-Suk, Viswanathan, Mohan, Schoonjans, Kristina, Auwerx, Johan, Guarente, Leonard Pershing
Published 2015

SirT3 suppresses hypoxia inducible factor 1α and tumor growth by inhibiting mitochondrial ROS production

by Emerling, B. M., Ricoult, S. J. H., Bell, Eric L., Guarente, Leonard Pershing
Published 2013

SIRT1 Mediates Central Circadian Control in the SCN by a Mechanism that Decays with Aging

by Chang, Hung-Chun, Guarente, Leonard Pershing
Published 2015

NAD + supplementation rejuvenates aged gut adult stem cells

by Igarashi, Masaki, Miura, Masaomi, Williams, Eric O, Jaksch, Frank, Kadowaki, Takashi, Yamauchi, Toshimasa, Guarente, Leonard Pershing
Published 2020

Metabolic and Neuropsychiatric Effects of Calorie Restriction and Sirtuins

by Libert, Sergiy V., Guarente, Leonard Pershing
Published 2014

Why haploinsufficiency persists

by Morrill, Summer A., Amon, Angelika B
Published 2020

The SirT3 Divining Rod Points to Oxidative Stress

by Bell, Eric L., Guarente, Leonard Pershing
Published 2014

Sirt1 mediates neuroprotection from mutant huntingtin by activation of the TORC1 and CREB transcriptional pathway

by Jeong, Hyunkyung, Cui, Libin, Supinski, Andrea, Savas, Jeffrey N., Mazzulli, Joseph R., Bordone, Laura, Krainc, Dimitri, Cohen, Dena E., Guarente, Leonard Pershing, Yates, John R., III
Published 2014

It takes two to tango: NAD+ and sirtuins in aging/longevity control

by Imai, Shin-ichiro, Guarente, Leonard Pershing
Published 2018

Caloric restriction blocks neuropathology and motor deficits in Machado-Joseph disease mouse models through SIRT1 pathway

by Cunha-Santos, Janete, Duarte-Neves, Joana, Carmona, Vitor, Pereira de Almeida, Luís, Cavadas, Cláudia, Guarente, Leonard Pershing
Published 2017

SIRT2 Ablation Has No Effect on Tubulin Acetylation in Brain, Cholesterol Biosynthesis or the Progression of Huntington's Disease Phenotypes In Vivo

by Bobrowska, Anna, Donmez Yalcin, Gizem, Weiss, Andreas, Guarente, Leonard Pershing, Bates, Gillian P.
Published 2012