Identification of CDCP1 as a hypoxia-inducible factor 2  (HIF-2 ) target gene that is associated with survival in clear cell renal cell carcinoma patients

Identification of CDCP1 as a hypoxia-inducible factor 2  (HIF-2 ) target gene that is associated with survival in clear cell renal cell carcinoma patients

CUB domain-containing protein 1 (CDCP1) is a transmembrane protein that is highly expressed in stem cells and frequently overexpressed and tyrosine-phosphorylated in cancer. CDCP1 promotes cancer cell metastasis. However, the mechanisms that regulate CDCP1 are not well-defined. Here we show that hyp...

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Bibliographic Details
Main Authors: Emerling, B. M. (Author), Benes, Cyril H. (Author), Poulogiannis, G. (Author), Courtney, K. (Author), Liu, H. (Author), Choo-Wing, R. (Author), Bellinger, Gary (Author), Tsukazawa, K. S. (Author), Brown, V. (Author), Signoretti, S. (Author), Soltoff, S. P. (Author), Cantley, Lewis C. (Author), Bell, Eric L. (Contributor)
Other Authors: Massachusetts Institute of Technology. Department of Biology (Contributor), Paul F. Glenn Center for Biology of Aging Research (Massachusetts Institute of Technology) (Contributor)
Format: Article
Language:English
Published: National Academy of Sciences (U.S.), 2013-09-09T18:16:17Z.
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