MCT1-mediated transport of a toxic molecule is an effective strategy for targeting glycolytic tumors

MCT1-mediated transport of a toxic molecule is an effective strategy for targeting glycolytic tumors

There is increasing evidence that oncogenic transformation modifies the metabolic program of cells. A common alteration is the upregulation of glycolysis, and efforts to target glycolytic enzymes for anticancer therapy are under way. Here, we performed a genome-wide haploid genetic screen to identif...

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Main Authors: Birsoy, Kivanc (Contributor), Wang, Tim (Contributor), Possemato, Richard (Contributor), Koch, Catherine E. (Contributor), Chen, Walter W. (Contributor), Hutchins, Amanda W. (Contributor), Gultekin, Yetis (Contributor), Carette, Jan E. (Author), Brummelkamp, Thijn R. (Author), Clish, Clary (Author), Yilmaz, Omer (Author), Peterson, Timothy Richard (Author), Sabatini, David (Author)
Other Authors: Massachusetts Institute of Technology. Department of Biology (Contributor), Koch Institute for Integrative Cancer Research at MIT (Contributor), Sabatini, David M. (Contributor), Yilmaz, Omer H. (Contributor), Peterson, Tim R. (Contributor)
Format: Article
Language:English
Published: Nature Publishing Group, 2013-07-10T14:30:10Z.
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