Environment Dictates Dependence on Mitochondrial Complex I for NAD+ and Aspartate Production and Determines Cancer Cell Sensitivity to Metformin

Environment Dictates Dependence on Mitochondrial Complex I for NAD+ and Aspartate Production and Determines Cancer Cell Sensitivity to Metformin

Metformin use is associated with reduced cancer mortality, but how metformin impacts cancer outcomes is controversial. Although metformin can act on cells autonomously to inhibit tumor growth, the doses of metformin that inhibit proliferation in tissue culture are much higher than what has been desc...

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Main Authors: Freinkman, Elizaveta (Author), Thomas, Craig J. (Author), Gui, Dan Yi (Contributor), Sullivan, Lucas Bryan (Contributor), Luengo, Alba (Contributor), Hosios, Aaron Marc (Contributor), Bush, Lauren N. (Contributor), Gitego, Nadege (Contributor), Davidson, Shawn M (Contributor), Vander Heiden, Matthew G. (Contributor)
Other Authors: Massachusetts Institute of Technology. Department of Biology (Contributor), Koch Institute for Integrative Cancer Research at MIT (Contributor)
Format: Article
Language:English
Published: Elsevier, 2018-07-11T20:19:18Z.
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