Environment Dictates Dependence on Mitochondrial Complex I for NAD+ and Aspartate Production and Determines Cancer Cell Sensitivity to Metformin

by Freinkman, Elizaveta, Thomas, Craig J., Gui, Dan Yi, Sullivan, Lucas Bryan, Luengo, Alba, Hosios, Aaron Marc, Bush, Lauren N., Gitego, Nadege, Davidson, Shawn M, Vander Heiden, Matthew G.
Published 2018

Aspartate is an endogenous metabolic limitation for tumour growth

by Sullivan, Lucas B., Luengo, Alba, Danai, Laura V., Bush, Lauren N., Diehl, Frances F., Hosios, Aaron M., Lau, Allison N., Elmiligy, Sarah, Lewis, Caroline A., Vander Heiden, Matthew G.
Published 2020