Developmental alterations in Huntington's disease neural cells and pharmacological rescue in cells and mice

Neural cultures derived from Huntington's disease (HD) patient-derived induced pluripotent stem cells were used for 'omics' analyses to identify mechanisms underlying neurodegeneration. RNA-seq analysis identified genes in glutamate and GABA signaling, axonal guidance and calcium infl...

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Main Authors: HD iPSC Consortium (Author), Lim, Ryan G (Author), Salazar, Lisa L (Author), Wilton, Daniel K (Author), King, Alvin R (Author), Stocksdale, Jennifer T (Author), Sharifabad, Delaram (Author), Lau, L Alice (Author), Stevens, Beth (Author), Reidling, Jack C (Author), Winokur, Sara T (Author), Casale, Malcolm S (Author), Thompson, Leslie M (Author), Pardo, Mónica (Author), Díaz-Barriga, A Gerardo García (Author), Straccia, Marco (Author), Sanders, Phil (Author), Alberch, Jordi (Author), Canals, Josep M (Author), Kaye, Julia A (Author), Dunlap, Mariah (Author), Jo, Lisa (Author), May, Hanna (Author), Mount, Elliot (Author), Anderson-Bergman, Cliff (Author), Haston, Kelly (Author), Finkbeiner, Steven (Author), Allen, Nicholas D (Author), Kemp, Paul J (Author), Atwal, Ranjit Singh (Author), Biagioli, Marta (Author), Gusella, James F (Author), MacDonald, Marcy E (Author), Akimov, Sergey S (Author), Arbez, Nicolas (Author), Stewart, Jacqueline (Author), Ross, Christopher A (Author), Mattis, Virginia B (Author), Tom, Colton M (Author), Ornelas, Loren (Author), Sahabian, Anais (Author), Lenaeus, Lindsay (Author), Mandefro, Berhan (Author), Sareen, Dhruv (Author), Svendsen, Clive N (Author), Kedaigle, Amanda Joy (Contributor), Wasylenko, Theresa Anne (Contributor), Yildirim, Ferah (Contributor), Ng, Christopher W. (Contributor), Milani, Pamela (Contributor), Housman, David E (Contributor), Fraenkel, Ernest (Contributor)
Other Authors: Massachusetts Institute of Technology. Department of Biological Engineering (Contributor), Massachusetts Institute of Technology. Department of Biology (Contributor), Koch Institute for Integrative Cancer Research at MIT (Contributor)
Format: Article
Language:English
Published: Springer Nature, 2018-06-22T14:43:03Z.
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