Crystal Structure of the Minimal Cas9 from Campylobacter jejuni Reveals the Molecular Diversity in the CRISPR-Cas9 Systems

Crystal Structure of the Minimal Cas9 from Campylobacter jejuni Reveals the Molecular Diversity in the CRISPR-Cas9 Systems

The RNA-guided endonuclease Cas9 generates a double-strand break at DNA target sites complementary to the guide RNA and has been harnessed for the development of a variety of new technologies, such as genome editing. Here, we report the crystal structures of Campylobacter jejuni Cas9 (CjCas9), one o...

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Bibliographic Details
Main Authors: Yamada, Mari (Author), Watanabe, Yuto (Author), Hirano, Hisato (Author), Ran, F. Ann (Author), Nakane, Takanori (Author), Ishitani, Ryuichiro (Author), Nishimasu, Hiroshi (Author), Nureki, Osamu (Author), Gootenberg, Jonathan S (Contributor), Zhang, Feng (Contributor)
Other Authors: Massachusetts Institute of Technology. Department of Biological Engineering (Contributor), Massachusetts Institute of Technology. Department of Brain and Cognitive Sciences (Contributor), McGovern Institute for Brain Research at MIT (Contributor)
Format: Article
Language:English
Published: Elsevier, 2018-04-25T17:38:12Z.
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