Deletion of DXZ4 on the human inactive X chromosome alters higher-order genome architecture

During interphase, the inactive X chromosome (Xi) is largely transcriptionally silent and adopts an unusual 3D configuration known as the "Barr body." Despite the importance of X chromosome inactivation, little is known about this 3D conformation. We recently showed that in humans the Xi c...

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Bibliographic Details
Main Authors: Darrow, Emily M. (Author), Huntley, Miriam H. (Author), Dudchenko, Olga (Author), Stamenova, Elena K. (Author), Durand, Neva C. (Author), Sun, Zhuo (Author), Huang, Su-Chen (Author), Sanborn, Adrian L. (Author), Machol, Ido (Author), Shamim, Muhammad (Author), Seberg, Andrew P. (Author), Chadwick, Brian P. (Author), Aiden, Erez Lieberman (Author), Lander, Eric Steven (Contributor)
Other Authors: Massachusetts Institute of Technology. Department of Biology (Contributor)
Format: Article
Language:English
Published: Proceedings of the National Academy of Sciences, 2018-04-17T17:51:38Z.
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