Crystal Structure of Staphylococcus aureus Cas9

Crystal Structure of Staphylococcus aureus Cas9

Summary The RNA-guided DNA endonuclease Cas9 cleaves double-stranded DNA targets with a protospacer adjacent mot if (PAM) and complementarity to the guide RNA. Recently, we harnessed Staphylococcus aureus Cas9 (SaCas9), which is significantly smaller than Streptococcus pyogenes Cas9 (SpCas9), to fac...

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Bibliographic Details
Main Authors: Nishimasu, Hiroshi (Author), Ran, F. Ann (Author), Kurabayashi, Arisa (Author), Ishitani, Ryuichiro (Author), Nureki, Osamu (Author), Cong, Le (Contributor), Yan, Winston Xia (Contributor), Zetsche, Bernd (Contributor), Li, Yinqing (Contributor), Zhang, Feng (Contributor)
Other Authors: Institute for Medical Engineering and Science (Contributor), Massachusetts Institute of Technology. Department of Biological Engineering (Contributor), Massachusetts Institute of Technology. Department of Brain and Cognitive Sciences (Contributor), McGovern Institute for Brain Research at MIT (Contributor)
Format: Article
Language:English
Published: Elsevier, 2017-12-13T14:35:53Z.
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