SHMT2 drives glioma cell survival in ischaemia but imposes a dependence on glycine clearance

SHMT2 drives glioma cell survival in ischaemia but imposes a dependence on glycine clearance

Cancer cells adapt their metabolic processes to support rapid proliferation, but less is known about how cancer cells alter metabolism to promote cell survival in a poorly vascularized tumour microenvironment1, 2, 3. Here we identify a key role for serine and glycine metabolism in the survival of br...

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Main Authors: Kami, Kenjiro (Author), Shelton, Laura M. (Author), Ramkissoon, Shakti H. (Author), Ligon, Keith L. (Author), Snuderl, Matija (Author), Kim, Dohoon (Contributor), Fiske, Brian Prescott (Contributor), Birsoy, Kivanc (Contributor), Freinkman, Elizaveta (Contributor), Possemato, Richard (Contributor), Chudnovsky, Yakov (Contributor), Chen, Walter W. (Contributor), Cantor, Jason R. (Contributor), Gui, Dan Yi (Contributor), Kwon, ManJae (Contributor), Kang, Seong Woo (Contributor), Vander Heiden, Matthew G. (Contributor), Sabatini, David (Contributor), Pacold, Michael Edward (Author)
Other Authors: Harvard University- (Contributor), Massachusetts Institute of Technology. Department of Biology (Contributor), Whitehead Institute for Biomedical Research (Contributor), Koch Institute for Integrative Cancer Research at MIT (Contributor), Pacold, Michael E (Contributor)
Format: Article
Language:English
Published: Nature Publishing Group, 2017-01-25T17:35:37Z.
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