Master Transcription Factors and Mediator Establish Super-Enhancers at Key Cell Identity Genes

Master Transcription Factors and Mediator Establish Super-Enhancers at Key Cell Identity Genes

Master transcription factors Oct4, Sox2, and Nanog bind enhancer elements and recruit Mediator to activate much of the gene expression program of pluripotent embryonic stem cells (ESCs). We report here that the ESC master transcription factors form unusual enhancer domains at most genes that control...

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Bibliographic Details
Main Authors: Whyte, Warren A (Author), Orlando, David A (Author), Hnisz, Denes (Author), Abraham, Brian J (Author), Lin, Charles Y (Author), Kagey, Michael H (Author), Rahl, Peter B (Author), Lee, Tong Ihn (Author), Young, Richard A (Author), Young, Richard A. (Contributor)
Other Authors: Massachusetts Institute of Technology. Department of Biology (Contributor), Whitehead Institute for Biomedical Research (Contributor)
Format: Article
Language:English
Published: Elsevier, 2016-08-11T15:32:10Z.
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