Transcriptional Regulation and Its Misregulation in Disease

by Lee, Tong Ihn, Young, Richard A, Young, Richard A.
Published 2016

Chromatin proteomic profiling reveals novel proteins associated with histone-marked genomic regions

by Ji, Xiong, Abraham, Brian J., Lee, Tong Ihn, Jaenisch, Rudolf, Bradner, James E., Young, Richard A., Dadon, Daniel Benjamin
Published 2015

Convergence of Developmental and Oncogenic Signaling Pathways at Transcriptional Super-Enhancers

by Hnisz, Denes, Schuijers, Jurian, Lin, Charles Y, Abraham, Brian J, Lee, Tong Ihn, Bradner, James E, Weintraub, Abraham Selby, Young, Richard A.
Published 2017

Super-Enhancers in the Control of Cell Identity and Disease

by Hnisz, Denes, Abraham, Brian Joseph, Lee, Tong Ihn, Lau, Ashley, Saint-Andre, Violaine, Sigova, Alla A., Hoke, Heather Ashley, Young, Richard A.
Published 2016

Transcriptional Amplification in Tumor Cells with Elevated c-Myc

by Lin, Charles Y., Loven, Jakob, Rahl, Peter B, Paranal, Ronald M, Burge, Christopher B., Bradner, James E., Lee, Tong Ihn, Young, Richard A
Published 2014

Models of human core transcriptional regulatory circuitries

by Saint-André, Violaine, Federation, Alexander J., Lin, Charles Y., Abraham, Brian J., Lee, Tong Ihn, Bradner, James E., Reddy, Jessica, Young, Richard A.
Published 2017

Transcriptional Dysregulation of MYC Reveals Common Enhancer-Docking Mechanism

by Schuijers, Jurian, Day, Daniel Sindt, Hnisz, Denes, Lee, Tong Ihn, Manteiga, John Colonnese, Weintraub, Abraham Selby, Zamudio Montes de Oca, Alicia, Young, Richard A.
Published 2018

Selective Inhibition of Tumor Oncogenes by Disruption of Super-Enhancers

by Loven, Jakob, Hoke, Heather Ashley, Lin, Charles Y., Lau, Ashley, Orlando, David A., Vakoc, Christopher R., Bradner, James E., Lee, Tong Ihn, Young, Richard A.
Published 2014

Revisiting Global Gene Expression Analysis

by Loven, Jakob, Orlando, David A., Sigova, Alla A, Lin, Charles Y., Rahl, Peter B, Burge, Christopher B., Levens, David L, Lee, Tong Ihn, Young, Richard A
Published 2015

Control of Cell Identity Genes Occurs in Insulated Neighborhoods in Mammalian Chromosomes

by Dowen, Jill M, Fan, Zi Peng, Hnisz, Denes, Ren, Gang, Abraham, Brian J, Weintraub, Abraham S, Schuijers, Jurian, Lee, Tong Ihn, Zhao, Keji, Zhang, Lyndon Nuoxi, Young, Richard A.
Published 2016

Master Transcription Factors and Mediator Establish Super-Enhancers at Key Cell Identity Genes

by Whyte, Warren A, Orlando, David A, Hnisz, Denes, Abraham, Brian J, Lin, Charles Y, Kagey, Michael H, Rahl, Peter B, Lee, Tong Ihn, Young, Richard A, Young, Richard A.
Published 2016

Genome-wide localization of small molecules

by Anders, Lars, Guenther, Matthew G., Qi, Jun, Fan, Zi Peng, Marineau, Jason J, Rahl, Peter B, Sigova, Alla A, Smith, William B, Lee, Tong Ihn, Bradner, James E., Young, Richard A., Loven, Jakob
Published 2015

3D Chromosome Regulatory Landscape of Human Pluripotent Cells

by Ji, Xiong, Powell, Benjamin E, Shachar, Sigal, Hnisz, Denes, Pegoraro, Gianluca, Lee, Tong Ihn, Misteli, Tom, Dadon, Daniel Benjamin, Fan, Zi Peng, Borges-Rivera, Diego Ramon, Weintraub, Abraham Selby, Jaenisch, Rudolf, Young, Richard A.
Published 2017

CDK7-Dependent Transcriptional Addiction in Triple-Negative Breast Cancer

by Wang, Yubao, Zhang, Tinghu, Kwiatkowski, Nicholas, Abraham, Brian J, Lee, Tong Ihn, Xie, Shaozhen, Yuzugullu, Haluk, Von, Thanh, Li, Heyuan, Lin, Ziao, Stover, Daniel G, Lim, Elgene, Wang, Zhigang C, Iglehart, J. Dirk, Gray, Nathanael S, Zhao, Jean J, Young, Richard A.
Published 2017

RNA-Mediated Feedback Control of Transcriptional Condensates

by Henninger, Jonathan E, Oksuz, Ozgur, Shrinivas, Krishna, Sagi, Ido, LeRoy, Gary, Zheng, Ming M, Andrews, J Owen, Zamudio, Alicia V, Lazaris, Charalampos, Hannett, Nancy M, Lee, Tong Ihn, Sharp, Phillip A, Cissé, Ibrahim I, Chakraborty, Arup K, Young, Richard A
Published 2022

A Systematic Approach to Identify Candidate Transcription Factors that Control Cell Identity

by D'Alessio, Ana C, Fan, Zi Peng, Wert, Katherine J, Baranov, Petr, Cohen, Malkiel A, Saini, Janmeet S, Cohick, Evan, Charniga, Carol, Hannett, Nancy M, Young, Michael J, Temple, Sally, Jaenisch, Rudolf, Lee, Tong Ihn, Young, Richard A, Dadon, Daniel Benjamin, Young, Richard A.
Published 2016

Small genomic insertions form enhancers that misregulate oncogenes

by Hnisz, Denes, Li, Zhaodong, Weichert-Leahey, Nina, Rahman, Sunniyat, Liu, Yu, Etchin, Julia, Li, Benshang, Shen, Shuhong, Zhang, Jinghui, Look, A. Thomas, Mansour, Marc R., Abraham, Brian Joseph, Weintraub, Abraham Selby, Kwiatkowski, Nick, Li, Charles Han, Lee, Tong Ihn, Young, Richard A.
Published 2017

Transcription Factors Activate Genes through the Phase-Separation Capacity of Their Activation Domains

by Klein, Isaac A., Sabari, Benjamin R., Dall'Agnese, Alessandra, Coffey, Eliot L., Zamudio, Alicia V., Manteiga, John C., Hannett, Nancy M., Abraham, Brian J., Afeyan, Lena K., Guo, Yang E., Schuijers, Jurian, Lee, Tong Ihn, Taatjes, Dylan J., Young, Richard A., Shrinivas, Krishna,Ph. D.Massachusetts Institute of Technology, Li, Charles H.
Published 2020

Coactivator condensation at super-enhancers links phase separation and gene control

by Sabari, Benjamin R., Dall'Agnese, Alessandra, Boija, Ann, Klein, Isaac A., Abraham, Brian J., Hannett, Nancy M., Guo, Yang E., Day, Daniel S., Schuijers, Jurian, Hnisz, Denes, Lee, Tong Ihn, Coffey, Eliot Leo, Shrinivas, Krishna, Zamudio Montes de Oca, Alicia, Manteiga, John Colonnese, Li, Charles Han, Vasile, Eliza, Cisse, Ibrahim I, Chakraborty, Arup K, Sharp, Phillip A., Young, Richard A.
Published 2019

Mediator Condensates Localize Signaling Factors to Key Cell Identity Genes

by Zamudio Montes de Oca, Alicia, Dall'Agnese, Alessandra, Henninger, Jonathan E., Manteiga, John Colonnese, Afeyan, Lena K., Hannett, Nancy M., Coffey, Eliot Leo, Li, Charles Han, Oksuz, Ozgur, Sabari, Benjamin R., Boija, Ann, Klein, Isaac A., Hawken, Susana W, Spille, Jan Hendrik, Cisse, Ibrahim I, Abraham, Brian Joseph, Lee, Tong Ihn, Taatjes, Dylan J., Schuijers, Jurian, Young, Richard A.
Published 2021