Foxa2 and Cdx2 cooperate with Nkx2-1 to inhibit lung adenocarcinoma metastasis

Foxa2 and Cdx2 cooperate with Nkx2-1 to inhibit lung adenocarcinoma metastasis

Despite the fact that the majority of lung cancer deaths are due to metastasis, the molecular mechanisms driving metastatic progression are poorly understood. Here, we present evidence that loss of Foxa2 and Cdx2 synergizes with loss of Nkx2-1 to fully activate the metastatic program. These three li...

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Main Authors: Li, Carman Man-Chung (Contributor), Gocheva, Vasilena (Contributor), Wang, Shi Yun (Contributor), Date, Saya R. (Contributor), Ng, Sheng Rong (Contributor), Whittaker, Charles A. (Contributor), Bronson, Roderick T. (Author), Snyder, Eric L. (Author), Oudin, Madeleine Julie (Contributor), Gertler, Frank (Contributor), Bhutkar, Arjun (Author), Jacks, Tyler E (Author)
Other Authors: Massachusetts Institute of Technology. Department of Biology (Contributor), Massachusetts Institute of Technology. Department of Mechanical Engineering (Contributor), Koch Institute for Integrative Cancer Research at MIT (Contributor), Bhutkar, Arjun (AJ) (Contributor), Jacks, Tyler E. (Contributor)
Format: Article
Language:English
Published: Cold Spring Harbor Laboratory Press, 2016-04-01T20:58:52Z.
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