Conserved epigenomic signals in mice and humans reveal immune basis of Alzheimer's disease

Conserved epigenomic signals in mice and humans reveal immune basis of Alzheimer's disease

Alzheimer's disease (AD) is a severe age-related neurodegenerative disorder characterized by accumulation of amyloid-β plaques and neurofibrillary tangles, synaptic and neuronal loss, and cognitive decline. Several genes have been implicated in AD, but chromatin state alterations during neurode...

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Main Authors: Gjoneska, Elizabeta (Contributor), Pfenning, Andreas R. (Contributor), Mathys, Hansruedi (Contributor), Quon, Gerald (Contributor), Kundaje, Anshul (Contributor), Tsai, Li-Huei (Contributor), Kellis, Manolis (Contributor)
Other Authors: Massachusetts Institute of Technology. Computer Science and Artificial Intelligence Laboratory (Contributor), Massachusetts Institute of Technology. Department of Brain and Cognitive Sciences (Contributor), Massachusetts Institute of Technology. Department of Electrical Engineering and Computer Science (Contributor), Picower Institute for Learning and Memory (Contributor)
Format: Article
Language:English
Published: American Association for the Advancement of Science (AAAS), 2016-01-06T18:14:42Z.
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