Quantifying cholesterol synthesis in vivo using 2H2O: enabling back-to-back studies in the same subject

Quantifying cholesterol synthesis in vivo using 2H2O: enabling back-to-back studies in the same subject

The advantages of using 2H2O to quantify cholesterol synthesis include i) homogeneous precursor labeling, ii) incorporation of 2H via multiple pathways, and iii) the ability to perform long-term studies in free-living subjects. However, there are two concerns. First, the t1/2 of tracer in body water...

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Bibliographic Details
Main Authors: Stephen F. Previs, Ablatt Mahsut, Alison Kulick, Keiana Dunn, Genevieve Andrews-Kelly, Christopher Johnson, Gowri Bhat, Kithsiri Herath, Paul L. Miller, Sheng-Ping Wang, Karim Azer, Jing Xu, Douglas G. Johns, Brian K. Hubbard, Thomas P. Roddy
Format: Article
Language:English
Published: Elsevier 2011-07-01
Series:Journal of Lipid Research
Subjects:
stable isotopes
mass spectrometry
kinetic biomarker
dyslipidemia
cardiovascular disease
Online Access:http://www.sciencedirect.com/science/article/pii/S002222752037036X

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http://www.sciencedirect.com/science/article/pii/S002222752037036X

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