Somatic genome editing with the RCAS-TVA-CRISPR-Cas9 system for precision tumor modeling

Somatic genome editing with the RCAS-TVA-CRISPR-Cas9 system for precision tumor modeling

Accurate recapitulation of human disease in animal models requires generation of complex and heterogeneous genetic variation. Here the authors combine RCAS-TVA with CRISPR-Cas9 to generate mouse models of cancer.

Bibliographic Details
Main Authors: Barbara Oldrini, Álvaro Curiel-García, Carolina Marques, Veronica Matia, Özge Uluçkan, Osvaldo Graña-Castro, Raul Torres-Ruiz, Sandra Rodriguez-Perales, Jason T. Huse, Massimo Squatrito
Format: Article
Language:English
Published: Nature Publishing Group 2018-04-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-018-03731-w

Internet

https://doi.org/10.1038/s41467-018-03731-w

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