Combination of dextromethorphan and memantine in treating bipolar spectrum disorder: a 12-week double-blind randomized clinical trial

Combination of dextromethorphan and memantine in treating bipolar spectrum disorder: a 12-week double-blind randomized clinical trial

Abstract Background The aim of this study is to determine whether adding combination of agents with anti-inflammatory and neurotrophic effects is more efficacious than mood stabilizer alone in improving clinical symptoms, plasma brain-derived neurotrophic factor (BDNF), cytokine levels, and metaboli...

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Main Authors: Sheng-Yu Lee, Tzu-Yun Wang, Shiou-Lan Chen, Yun-Hsuan Chang, Po-See Chen, San-Yuan Huang, Nian-Sheng Tzeng, Liang-Jen Wang, I-Hui Lee, Kao-Ching Chen, Yen-Kuang Yang, Jau-Shyong Hong, Ru-Band Lu
Format: Article
Language:English
Published: SpringerOpen 2020-03-01
Series:International Journal of Bipolar Disorders
Subjects:
Bipolar spectrum disorder
Bipolar II disorder
Dextromethorphan
Memantine
Cytokines
BDNF
Online Access:http://link.springer.com/article/10.1186/s40345-019-0174-8

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http://link.springer.com/article/10.1186/s40345-019-0174-8

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