The pentose phosphate pathway regulates chronic neuroinflammation and dopaminergic neurodegeneration

by Dezhen Tu, Yun Gao, Ru Yang, Tian Guan, Jau-Shyong Hong, Hui-Ming Gao
Published 2019-12-01

Through Reducing ROS Production, IL-10 Suppresses Caspase-1-Dependent IL-1β Maturation, thereby Preventing Chronic Neuroinflammation and Neurodegeneration

by Yun Gao, Dezhen Tu, Ru Yang, Chun-Hsien Chu, Jau-Shyong Hong, Hui-Ming Gao
Published 2020-01-01

Low dose dextromethorphan attenuates moderate experimental autoimmune encephalomyelitis by inhibiting NOX2 and reducing peripheral immune cells infiltration in the spinal cord

by Olga V. Chechneva, Florian Mayrhofer, Daniel J. Daugherty, David E. Pleasure, Jau-Shyong Hong, Wenbin Deng
Published 2011-10-01

Early-Released Interleukin-10 Significantly Inhibits Lipopolysaccharide-Elicited Neuroinflammation In Vitro

by Yubao Wang, Pei Yu, Yi Li, Zhan Zhao, Xiaomei Wu, Lu Zhang, Jing Feng, Jau-Shyong Hong
Published 2021-08-01

Transcriptional Factor NF-κB as a Target for Therapy in Parkinson's Disease

by Patrick M. Flood, Li Qian, Lynda J. Peterson, Feng Zhang, Jing-Shan Shi, Hui-Ming Gao, Jau-Shyong Hong
Published 2011-01-01

Hypertension and Diagnosis of Parkinson’s Disease: A Meta-Analysis of Cohort Studies

by Liyan Hou, Qiujuan Li, Liping Jiang, Hongyan Qiu, Chengyan Geng, Jau-Shyong Hong, Huihua Li, Huihua Li, Qingshan Wang
Published 2018-03-01

Microglial activation contributes to cognitive impairments in rotenone-induced mouse Parkinson’s disease model

by Dongdong Zhang, Sheng Li, Liyan Hou, Lu Jing, Zhengzheng Ruan, Bingjie Peng, Xiaomeng Zhang, Jau-Shyong Hong, Jie Zhao, Qingshan Wang
Published 2021-01-01

Valproate is protective against 6-OHDA-induced dopaminergic neurodegeneration in rodent midbrain: A potential role of BDNF up-regulation

by Ching-Long Lai, Chun-Chung Lu, Hui-Ching Lin, Yueh-Feng Sung, Yi-Pin Wu, Jau-Shyong Hong, Giia-Sheun Peng
Published 2019-01-01

Neuropsychotoxic and Neuroprotective Potentials of Dextromethorphan and Its Analogs

by Eun-Joo Shin, Jae-Hyung Bach, Sung Youl Lee, Jeong Min Kim, Jinhwa Lee, Jau-Shyong Hong, Toshitaka Nabeshima, Hyoung-Chun Kim
Published 2011-01-01

NADPH oxidase-derived H2O2 mediates the regulatory effects of microglia on astrogliosis in experimental models of Parkinson's disease

by Liyan Hou, Xueying Zhou, Cong Zhang, Ke Wang, Xiaofang Liu, Yuning Che, Fuqiang Sun, Huihua Li, Qingshan Wang, Dan Zhang, Jau-Shyong Hong
Published 2017-08-01

Estrogen receptor α phosphorylated at Ser216 confers inflammatory function to mouse microglia

by Sawako Shindo, Shih-Heng Chen, Saki Gotoh, Kosuke Yokobori, Hao Hu, Manas Ray, Rick Moore, Kiyoshi Nagata, Jennifer Martinez, Jau-Shyong Hong, Masahiko Negishi
Published 2020-07-01

A novel role of NLRP3-generated IL-1β in the acute-chronic transition of peripheral lipopolysaccharide-elicited neuroinflammation: implications for sepsis-associated neurodegenerat...

by Zhan Zhao, Yubao Wang, Ran Zhou, Yi Li, Yun Gao, Dezhen Tu, Belinda Wilson, Sheng Song, Jing Feng, Jau-Shyong Hong, Jerrel L. Yakel
Published 2020-02-01

The Deacetylase HDAC6 Mediates Endogenous Neuritic Tau Pathology

by Jui-Heng Tseng, Ling Xie, Sheng Song, Youmei Xie, Lauren Allen, Deepa Ajit, Jau-Shyong Hong, Xian Chen, Rick B. Meeker, Todd J. Cohen
Published 2017-08-01

Dextromethorphan Inhibits Activations and Functions in Dendritic Cells

by Der-Yuan Chen, Pei-Shan Song, Jau-Shyong Hong, Ching-Liang Chu, I-Horng Pan, Yi-Ming Chen, Ching-Hsiung Lin, Sheng-Hao Lin, Chi-Chen Lin
Published 2013-01-01

Microglial Nox2 Plays a Key Role in the Pathogenesis of Experimental Autoimmune Encephalomyelitis

by Chih-Fen Hu, Chih-Fen Hu, San-Pin Wu, Gu-Jiun Lin, Chi-Chang Shieh, Chih-Sin Hsu, Jing-Wun Chen, Shih-Heng Chen, Jau-Shyong Hong, Shyi-Jou Chen, Shyi-Jou Chen, Shyi-Jou Chen
Published 2021-04-01

Ginsenoside Re protects methamphetamine-induced dopaminergic neurotoxicity in mice via upregulation of dynorphin-mediated κ-opioid receptor and downregulation of substance P-mediat...

by Duy-Khanh Dang, Eun-Joo Shin, Dae-Joong Kim, Hai-Quyen Tran, Ji Hoon Jeong, Choon-Gon Jang, Seung-Yeol Nah, Jung Hwan Jeong, Jae Kyung Byun, Sung Kwon Ko, Guoying Bing, Jau-Shyong Hong, Hyoung-Chun Kim
Published 2018-02-01

Combination of dextromethorphan and memantine in treating bipolar spectrum disorder: a 12-week double-blind randomized clinical trial

by Sheng-Yu Lee, Tzu-Yun Wang, Shiou-Lan Chen, Yun-Hsuan Chang, Po-See Chen, San-Yuan Huang, Nian-Sheng Tzeng, Liang-Jen Wang, I-Hui Lee, Kao-Ching Chen, Yen-Kuang Yang, Jau-Shyong Hong, Ru-Band Lu
Published 2020-03-01

Inflammation's Association with Metabolic Profiles before and after a Twelve-Week Clinical Trial in Drug-Naïve Patients with Bipolar II Disorder.

by Sheng-Yu Lee, Shiou-Lan Chen, Yun-Hsuan Chang, Po See Chen, San-Yuan Huang, Nian-Sheng Tzeng, Yu-Shan Wang, Liang-Jen Wang, I Hui Lee, Tzu-Yun Wang, Tzung Lieh Yeh, Yen Kuang Yang, Jau-Shyong Hong, Ru-Band Lu
Published 2013-01-01

Memory Impairment and Plasma BDNF Correlates of the BDNF Val66Met Polymorphism in Patients With Bipolar II Disorder

by Yun-Hsuan Chang, Yun-Hsuan Chang, Yun-Hsuan Chang, Tzu-Yun Wang, Tzu-Yun Wang, Sheng-Yu Lee, Sheng-Yu Lee, Sheng-Yu Lee, Sheng-Yu Lee, Shiou-Lan Chen, Shiou-Lan Chen, Shiou-Lan Chen, Chih-Chun Huang, Po See Chen, Po See Chen, Po See Chen, Yen Kuang Yang, Yen Kuang Yang, Yen Kuang Yang, Jau-Shyong Hong, Ru-Band Lu, Ru-Band Lu
Published 2018-11-01