Integrated Data Analysis of Six Clinical Studies Points Toward Model-Informed Precision Dosing of Tamoxifen

Integrated Data Analysis of Six Clinical Studies Points Toward Model-Informed Precision Dosing of Tamoxifen

IntroductionAt tamoxifen standard dosing, ∼20% of breast cancer patients do not reach proposed target endoxifen concentrations >5.97 ng/mL. Thus, better understanding the large interindividual variability in tamoxifen pharmacokinetics (PK) is crucial. By applying non-linear mixed-effects (NLM...

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Bibliographic Details
Main Authors: Lena Klopp-Schulze, Anna Mueller-Schoell, Patrick Neven, Stijn L. W. Koolen, Ron H. J. Mathijssen, Markus Joerger, Charlotte Kloft
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-03-01
Series:Frontiers in Pharmacology
Subjects:
tamoxifen
modeling
simulation
pharmacokinetics
individualized dosing
model-informed precision dosing
Online Access:https://www.frontiersin.org/article/10.3389/fphar.2020.00283/full

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https://www.frontiersin.org/article/10.3389/fphar.2020.00283/full

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