Thermoresponsive Copolymer Nanovectors Improve the Bioavailability of Retrograde Inhibitors in the Treatment of Leishmania Infections

Thermoresponsive Copolymer Nanovectors Improve the Bioavailability of Retrograde Inhibitors in the Treatment of Leishmania Infections

Clinical manifestations of leishmaniasis range from self-healing, cutaneous lesions to fatal infections of the viscera. With no preventative Leishmania vaccine available, the frontline option against leishmaniasis is chemotherapy. Unfortunately, currently available anti-Leishmania drugs face several...

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Bibliographic Details
Main Authors: Evan Craig, Anna Calarco, Raffaele Conte, Veronica Ambrogi, Giovanna Gomez d’Ayala, Philip Alabi, Jason K. Sello, Pierfrancesco Cerruti, Peter E. Kima
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-08-01
Series:Frontiers in Cellular and Infection Microbiology
Subjects:
Leishmania
Retro-2
retrograde inhibitors
thermoresponsive polymers
nanoaggregates
encapsulation
Online Access:https://www.frontiersin.org/articles/10.3389/fcimb.2021.702676/full

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https://www.frontiersin.org/articles/10.3389/fcimb.2021.702676/full

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