Intravacuolar Pathogens Hijack Host Extracellular Vesicle Biogenesis to Secrete Virulence Factors

by Anna Gioseffi, Mariola J. Edelmann, Peter E. Kima
Published 2021-04-01

Leishmania amazonensis amastigotes highly express a tryparedoxin peroxidase isoform that increases parasite resistance to macrophage antimicrobial defenses and fosters parasite vir...

by Calvin A Henard, Eric D Carlsen, Christie Hay, Peter E Kima, Lynn Soong
Published 2014-07-01

Identification of Leishmania proteins preferentially released in infected cells using change mediated antigen technology (CMAT).

by Peter E Kima, J Alfredo Bonilla, Eumin Cho, Blaise Ndjamen, Johnathan Canton, Nicole Leal, Martin Handfield
Published 2010-10-01

Miransertib (ARQ 092), an orally-available, selective Akt inhibitor is effective against Leishmania.

by Devki Nandan, Naixin Zhang, Yi Yu, Brian Schwartz, Stella Chen, Peter E Kima, Neil E Reiner
Published 2018-01-01

Structurally optimized analogs of the retrograde trafficking inhibitor Retro-2cycl limit Leishmania infections.

by Evan Craig, Charles-Eugene Huyghues-Despointes, Chun Yu, Emma L Handy, Jason K Sello, Peter E Kima
Published 2017-05-01

Thermoresponsive Copolymer Nanovectors Improve the Bioavailability of Retrograde Inhibitors in the Treatment of Leishmania Infections

by Evan Craig, Anna Calarco, Raffaele Conte, Veronica Ambrogi, Giovanna Gomez d’Ayala, Philip Alabi, Jason K. Sello, Pierfrancesco Cerruti, Peter E. Kima
Published 2021-08-01