Drug Resistance in Non-Small Cell Lung Cancer: A Potential for NOTCH Targeting?

Drug Resistance in Non-Small Cell Lung Cancer: A Potential for NOTCH Targeting?

Drug resistance is a major cause for therapeutic failure in non-small cell lung cancer (NSCLC) leading to tumor recurrence and disease progression. Cell intrinsic mechanisms of resistance include changes in the expression of drug transporters, activation of pro-survival, and anti-apoptotic pathways,...

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Bibliographic Details
Main Authors: Venus Sosa Iglesias, Lorena Giuranno, Ludwig J. Dubois, Jan Theys, Marc Vooijs
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-07-01
Series:Frontiers in Oncology
Subjects:
non-small cell lung cancer
treatment resistance
NOTCH/gamma-secretase inhibitor
chemotherapy
targeted therapy
Online Access:https://www.frontiersin.org/article/10.3389/fonc.2018.00267/full

Internet

https://www.frontiersin.org/article/10.3389/fonc.2018.00267/full

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