Structures of teixobactin-producing nonribosomal peptide synthetase condensation and adenylation domains

The recently discovered antibiotic teixobactin is produced by uncultured soil bacteria. The antibiotic inhibits cell wall synthesis of Gram-positive bacteria by binding to precursors of cell wall building blocks, and therefore it is thought to be less vulnerable to development of resistance. Teixoba...

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Bibliographic Details
Main Authors: Kemin Tan, Min Zhou, Robert P. Jedrzejczak, Ruiying Wu, Raul A. Higuera, Dominika Borek, Gyorgy Babnigg, Andrzej Joachimiak
Format: Article
Language:English
Published: Elsevier 2020-01-01
Series:Current Research in Structural Biology
Subjects:
Online Access:http://www.sciencedirect.com/science/article/pii/S2665928X20300027