Extended Cleavage Specificity of Human Neutrophil Elastase, Human Proteinase 3, and Their Distant Ortholog Clawed Frog PR3—Three Elastases With Similar Primary but Different Extended Specificities and Stability

Extended Cleavage Specificity of Human Neutrophil Elastase, Human Proteinase 3, and Their Distant Ortholog Clawed Frog PR3—Three Elastases With Similar Primary but Different Extended Specificities and Stability

Serine proteases are major granule constituents of several of the human hematopoietic cell lineages. Four proteolytically active such proteases have been identified in human neutrophils: cathepsin G (hCG), N-elastase (hNE), proteinase 3 (hPR-3), and neutrophil serine protease 4 (hNSP-4). Here we pre...

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Bibliographic Details
Main Authors: Zhirong Fu, Michael Thorpe, Srinivas Akula, Gurdeep Chahal, Lars T. Hellman
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-10-01
Series:Frontiers in Immunology
Subjects:
neutrophilic granulocyte
serine protease
hematopoiesis
proteinase 3
N-elastase
amphibian
Online Access:https://www.frontiersin.org/article/10.3389/fimmu.2018.02387/full

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https://www.frontiersin.org/article/10.3389/fimmu.2018.02387/full

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