EpCAM ectodomain EpEX is a ligand of EGFR that counteracts EGF-mediated epithelial-mesenchymal transition through modulation of phospho-ERK1/2 in head and neck cancers.

EpCAM ectodomain EpEX is a ligand of EGFR that counteracts EGF-mediated epithelial-mesenchymal transition through modulation of phospho-ERK1/2 in head and neck cancers.

Head and neck squamous cell carcinomas (HNSCCs) are characterized by outstanding molecular heterogeneity that results in severe therapy resistance and poor clinical outcome. Inter- and intratumoral heterogeneity in epithelial-mesenchymal transition (EMT) was recently revealed as a major parameter of...

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Bibliographic Details
Main Authors: Min Pan, Henrik Schinke, Elke Luxenburger, Gisela Kranz, Julius Shakhtour, Darko Libl, Yuanchi Huang, Aljaž Gaber, Miha Pavšič, Brigita Lenarčič, Julia Kitz, Mark Jakob, Sabina Schwenk-Zieger, Martin Canis, Julia Hess, Kristian Unger, Philipp Baumeister, Olivier Gires
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2018-09-01
Series:PLoS Biology
Online Access:http://europepmc.org/articles/PMC6177200?pdf=render

Internet

http://europepmc.org/articles/PMC6177200?pdf=render

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