Repurposing the selective estrogen receptor modulator bazedoxifene to suppress gastrointestinal cancer growth

Repurposing the selective estrogen receptor modulator bazedoxifene to suppress gastrointestinal cancer growth

Abstract Excessive signaling through gp130, the shared receptor for the interleukin (IL)6 family of cytokines, is a common hallmark in solid malignancies and promotes their progression. Here, we established the in vivo utility of bazedoxifene, a steroid analog clinically approved for the treatment o...

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Bibliographic Details
Main Authors: Pathum Thilakasiri, Jennifer Huynh, Ashleigh R Poh, Chin Wee Tan, Tracy L Nero, Kelly Tran, Adam C Parslow, Shoukat Afshar‐Sterle, David Baloyan, Natalie J Hannan, Michael Buchert, Andrew Mark Scott, Michael DW Griffin, Frederic Hollande, Michael W Parker, Tracy L Putoczki, Matthias Ernst, Ashwini L Chand
Format: Article
Language:English
Published: Wiley 2019-04-01
Series:EMBO Molecular Medicine
Subjects:
colon cancer
gastric cancer
gp130
interleukin‐11
interleukin‐6
Online Access:https://doi.org/10.15252/emmm.201809539

Internet

https://doi.org/10.15252/emmm.201809539

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