Activity-modulating monoclonal antibodies to the human serine protease HtrA3 provide novel insights into regulating HtrA proteolytic activities.

by Harmeet Singh, Tracy L Nero, Yao Wang, Michael W Parker, Guiying Nie
Published 2014-01-01

Small molecule proprotein convertase inhibitors for inhibition of embryo implantation.

by Huiting Ho, Harmeet Singh, Sophea Heng, Tracy L Nero, Sarah Paule, Michael W Parker, Alan T Johnson, Guan-Sheng Jiao, Guiying Nie
Published 2013-01-01

Small Molecule Binding to Alzheimer Risk Factor CD33 Promotes Aβ Phagocytosis

by Luke A. Miles, Stefan J. Hermans, Gabriela A.N. Crespi, Jonathan H. Gooi, Larissa Doughty, Tracy L. Nero, Jasmina Markulić, Andreas Ebneth, Berthold Wroblowski, Daniel Oehlrich, Andrés A. Trabanco, Marie-Laure Rives, Ines Royaux, Nancy C. Hancock, Michael W. Parker
Published 2019-09-01

A dual role for the N-terminal domain of the IL-3 receptor in cell signalling

by Sophie E. Broughton, Timothy R. Hercus, Tracy L. Nero, Winnie L. Kan, Emma F. Barry, Mara Dottore, Karen S. Cheung Tung Shing, Craig J. Morton, Urmi Dhagat, Matthew P. Hardy, Nicholas J. Wilson, Matthew T. Downton, Christine Schieber, Timothy P. Hughes, Angel F. Lopez, Michael W. Parker
Published 2018-01-01

Repurposing the selective estrogen receptor modulator bazedoxifene to suppress gastrointestinal cancer growth

by Pathum Thilakasiri, Jennifer Huynh, Ashleigh R Poh, Chin Wee Tan, Tracy L Nero, Kelly Tran, Adam C Parslow, Shoukat Afshar‐Sterle, David Baloyan, Natalie J Hannan, Michael Buchert, Andrew Mark Scott, Michael DW Griffin, Frederic Hollande, Michael W Parker, Tracy L Putoczki, Matthias Ernst, Ashwini L Chand
Published 2019-04-01

Transitional changes in the CRP structure lead to the exposure of proinflammatory binding sites

by David Braig, Tracy L. Nero, Hans-Georg Koch, Benedict Kaiser, Xiaowei Wang, Jan R. Thiele, Craig J. Morton, Johannes Zeller, Jurij Kiefer, Lawrence A. Potempa, Natalie A. Mellett, Luke A. Miles, Xiao-Jun Du, Peter J. Meikle, Markus Huber-Lang, G. Björn Stark, Michael W. Parker, Karlheinz Peter, Steffen U. Eisenhardt
Published 2017-01-01

Dual Mechanism of Interleukin-3 Receptor Blockade by an Anti-Cancer Antibody

by Sophie E. Broughton, Timothy R. Hercus, Matthew P. Hardy, Barbara J. McClure, Tracy L. Nero, Mara Dottore, Huy Huynh, Hal Braley, Emma F. Barry, Winnie L. Kan, Urmi Dhagat, Pierre Scotney, Dallas Hartman, Samantha J. Busfield, Catherine M. Owczarek, Andrew D. Nash, Nicholas J. Wilson, Michael W. Parker, Angel F. Lopez
Published 2014-07-01